A genome-wide screen reveals that Dyrk1A kinase promotes nucleotide excision repair by preventing aberrant overexpression of cyclin D1 and p21

Nucleotide excision repair (NER) eliminates highly genotoxic solar UV-induced DNA photoproducts that otherwise stimulate malignant melanoma development. Here, a genome-wide loss-of-function screen, coupling CRISPR/Cas9 technology with a flow cytometry-based DNA repair assay, was used to identify nov...

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Detalles Bibliográficos
Autores principales: Bélanger, François, Roussel, Cassandra, Sawchyn, Christina, St-Hilaire, Edlie, Gezzar-Dandashi, Sari, Kimenyi Ishimwe, Aimé Boris, Mallette, Frédérick Antoine, Wurtele, Hugo, Drobetsky, Elliot
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339196/
https://www.ncbi.nlm.nih.gov/pubmed/37301510
http://dx.doi.org/10.1016/j.jbc.2023.104900

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