Inflammation as a therapeutic target in heart failure with preserved ejection fraction

Heart failure with preserved ejection fraction (HFpEF) accounts for around half of all cases of heart failure and may become the dominant type of heart failure in the near future. Unlike HF with reduced ejection fraction there are few evidence-based treatment strategies available. There is a signifi...

Descripción completa

Detalles Bibliográficos
Autores principales: Peh, Zhen Hui, Dihoum, Adel, Hutton, Dana, Arthur, J. Simon C., Rena, Graham, Khan, Faisel, Lang, Chim C., Mordi, Ify R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339321/
https://www.ncbi.nlm.nih.gov/pubmed/37456816
http://dx.doi.org/10.3389/fcvm.2023.1125687
_version_ 1785071819964809216
author Peh, Zhen Hui
Dihoum, Adel
Hutton, Dana
Arthur, J. Simon C.
Rena, Graham
Khan, Faisel
Lang, Chim C.
Mordi, Ify R.
author_facet Peh, Zhen Hui
Dihoum, Adel
Hutton, Dana
Arthur, J. Simon C.
Rena, Graham
Khan, Faisel
Lang, Chim C.
Mordi, Ify R.
author_sort Peh, Zhen Hui
collection PubMed
description Heart failure with preserved ejection fraction (HFpEF) accounts for around half of all cases of heart failure and may become the dominant type of heart failure in the near future. Unlike HF with reduced ejection fraction there are few evidence-based treatment strategies available. There is a significant unmet need for new strategies to improve clinical outcomes in HFpEF patients. Inflammation is widely thought to play a key role in HFpEF pathophysiology and may represent a viable treatment target. In this review focusing predominantly on clinical studies, we will summarise the role of inflammation in HFpEF and discuss potential therapeutic strategies targeting inflammation.
format Online
Article
Text
id pubmed-10339321
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-103393212023-07-14 Inflammation as a therapeutic target in heart failure with preserved ejection fraction Peh, Zhen Hui Dihoum, Adel Hutton, Dana Arthur, J. Simon C. Rena, Graham Khan, Faisel Lang, Chim C. Mordi, Ify R. Front Cardiovasc Med Cardiovascular Medicine Heart failure with preserved ejection fraction (HFpEF) accounts for around half of all cases of heart failure and may become the dominant type of heart failure in the near future. Unlike HF with reduced ejection fraction there are few evidence-based treatment strategies available. There is a significant unmet need for new strategies to improve clinical outcomes in HFpEF patients. Inflammation is widely thought to play a key role in HFpEF pathophysiology and may represent a viable treatment target. In this review focusing predominantly on clinical studies, we will summarise the role of inflammation in HFpEF and discuss potential therapeutic strategies targeting inflammation. Frontiers Media S.A. 2023-06-29 /pmc/articles/PMC10339321/ /pubmed/37456816 http://dx.doi.org/10.3389/fcvm.2023.1125687 Text en © 2023 Peh, Dihoum, Hutton, Arthur, Rena, Khan, Lang and Mordi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Peh, Zhen Hui
Dihoum, Adel
Hutton, Dana
Arthur, J. Simon C.
Rena, Graham
Khan, Faisel
Lang, Chim C.
Mordi, Ify R.
Inflammation as a therapeutic target in heart failure with preserved ejection fraction
title Inflammation as a therapeutic target in heart failure with preserved ejection fraction
title_full Inflammation as a therapeutic target in heart failure with preserved ejection fraction
title_fullStr Inflammation as a therapeutic target in heart failure with preserved ejection fraction
title_full_unstemmed Inflammation as a therapeutic target in heart failure with preserved ejection fraction
title_short Inflammation as a therapeutic target in heart failure with preserved ejection fraction
title_sort inflammation as a therapeutic target in heart failure with preserved ejection fraction
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339321/
https://www.ncbi.nlm.nih.gov/pubmed/37456816
http://dx.doi.org/10.3389/fcvm.2023.1125687
work_keys_str_mv AT pehzhenhui inflammationasatherapeutictargetinheartfailurewithpreservedejectionfraction
AT dihoumadel inflammationasatherapeutictargetinheartfailurewithpreservedejectionfraction
AT huttondana inflammationasatherapeutictargetinheartfailurewithpreservedejectionfraction
AT arthurjsimonc inflammationasatherapeutictargetinheartfailurewithpreservedejectionfraction
AT renagraham inflammationasatherapeutictargetinheartfailurewithpreservedejectionfraction
AT khanfaisel inflammationasatherapeutictargetinheartfailurewithpreservedejectionfraction
AT langchimc inflammationasatherapeutictargetinheartfailurewithpreservedejectionfraction
AT mordiifyr inflammationasatherapeutictargetinheartfailurewithpreservedejectionfraction

Ejemplares similares