Elevated levels of enteric IgA in an unimmunised mouse model of Hyper IgM syndrome derived from gut-associated secondary lymph organs even in the absence of germinal centres

INTRODUCTION: Patients with Human Hyper IgM syndromes (HIGM) developed pulmonary and gastrointestinal infections since infancy and most patients have mutations in the CD40 ligand (CD40L) gene. Most HIGM patients compared to healthy subjects have higher/similar IgM and lower IgG, and IgA serum concen...

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Detalles Bibliográficos
Autores principales: Hernandez-Cazares, Felipe, Maqueda-Alfaro, Raul Antonio, Lopez-Saucedo, Catalina, Martinez-Barnetche, Jesus, Yam-Puc, Juan Carlos, Estrada-Parra, Sergio, Flores-Romo, Leopoldo, Estrada-Garcia, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339347/
https://www.ncbi.nlm.nih.gov/pubmed/37457961
http://dx.doi.org/10.3389/fcimb.2023.1172021

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