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Regional contributions of D-serine to Alzheimer’s disease pathology in male App(NL–G–F/NL–G–F) mice

BACKGROUND: Neurodegenerative processes in Alzheimer’s disease (AD) are associated with excitotoxicity mediated by the N-methyl-D-aspartate receptor (NMDAR). D-Serine is an endogenous co-agonist necessary for NMDAR-mediated excitotoxicity. In the mammalian brain, it is produced by serine racemase (S...

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Detalles Bibliográficos
Autores principales:	Ni, Xiance, Inoue, Ran, Wu, Yi, Yoshida, Tomoyuki, Yaku, Keisuke, Nakagawa, Takashi, Saito, Takashi, Saido, Takaomi C., Takao, Keizo, Mori, Hisashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339350/ https://www.ncbi.nlm.nih.gov/pubmed/37455930 http://dx.doi.org/10.3389/fnagi.2023.1211067

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