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Biocompatible Alginate Film Crosslinked with Ca(2+) and Zn(2+) Possesses Antibacterial, Antiviral, and Anticancer Activities

[Image: see text] Alginate is a highly promising biopolymer due to its non-toxic and biodegradable properties. Alginate hydrogels are often fabricated by cross-linking sodium alginate with calcium cations and can be engineered with highly desirable enhanced physical and biological properties for bio...

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Autores principales: Cano-Vicent, Alba, Tuñón-Molina, Alberto, Bakshi, Hamid, Sabater i Serra, Roser, Alfagih, Iman M., Tambuwala, Murtaza M., Serrano-Aroca, Ángel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339430/
https://www.ncbi.nlm.nih.gov/pubmed/37457479
http://dx.doi.org/10.1021/acsomega.3c01935
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author Cano-Vicent, Alba
Tuñón-Molina, Alberto
Bakshi, Hamid
Sabater i Serra, Roser
Alfagih, Iman M.
Tambuwala, Murtaza M.
Serrano-Aroca, Ángel
author_facet Cano-Vicent, Alba
Tuñón-Molina, Alberto
Bakshi, Hamid
Sabater i Serra, Roser
Alfagih, Iman M.
Tambuwala, Murtaza M.
Serrano-Aroca, Ángel
author_sort Cano-Vicent, Alba
collection PubMed
description [Image: see text] Alginate is a highly promising biopolymer due to its non-toxic and biodegradable properties. Alginate hydrogels are often fabricated by cross-linking sodium alginate with calcium cations and can be engineered with highly desirable enhanced physical and biological properties for biomedical applications. This study reports on the anticancer, antiviral, antibacterial, in vitro, and in vivo toxicity, water absorption, and compound release properties of an alginate hydrogel crosslinked with calcium and different amounts of zinc cations. The results showed that the calcium alginate hydrogel film crosslinked with the highest amount of zinc showed similar water sorption properties to those of calcium alginate and released a suitable amount of zinc to provide anticancer activity against melanoma and colon cancer cells and has antibacterial properties against methicillin-resistant Staphylococcus epidermidis and antiviral activity against enveloped and non-enveloped viruses. This film is non-toxic in both in vitro in keratinocyte HaCaT cells and in vivo in the Caenorhabditis elegans model, which renders it especially promising for biomedical applications.
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spelling pubmed-103394302023-07-14 Biocompatible Alginate Film Crosslinked with Ca(2+) and Zn(2+) Possesses Antibacterial, Antiviral, and Anticancer Activities Cano-Vicent, Alba Tuñón-Molina, Alberto Bakshi, Hamid Sabater i Serra, Roser Alfagih, Iman M. Tambuwala, Murtaza M. Serrano-Aroca, Ángel ACS Omega [Image: see text] Alginate is a highly promising biopolymer due to its non-toxic and biodegradable properties. Alginate hydrogels are often fabricated by cross-linking sodium alginate with calcium cations and can be engineered with highly desirable enhanced physical and biological properties for biomedical applications. This study reports on the anticancer, antiviral, antibacterial, in vitro, and in vivo toxicity, water absorption, and compound release properties of an alginate hydrogel crosslinked with calcium and different amounts of zinc cations. The results showed that the calcium alginate hydrogel film crosslinked with the highest amount of zinc showed similar water sorption properties to those of calcium alginate and released a suitable amount of zinc to provide anticancer activity against melanoma and colon cancer cells and has antibacterial properties against methicillin-resistant Staphylococcus epidermidis and antiviral activity against enveloped and non-enveloped viruses. This film is non-toxic in both in vitro in keratinocyte HaCaT cells and in vivo in the Caenorhabditis elegans model, which renders it especially promising for biomedical applications. American Chemical Society 2023-06-28 /pmc/articles/PMC10339430/ /pubmed/37457479 http://dx.doi.org/10.1021/acsomega.3c01935 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Cano-Vicent, Alba
Tuñón-Molina, Alberto
Bakshi, Hamid
Sabater i Serra, Roser
Alfagih, Iman M.
Tambuwala, Murtaza M.
Serrano-Aroca, Ángel
Biocompatible Alginate Film Crosslinked with Ca(2+) and Zn(2+) Possesses Antibacterial, Antiviral, and Anticancer Activities
title Biocompatible Alginate Film Crosslinked with Ca(2+) and Zn(2+) Possesses Antibacterial, Antiviral, and Anticancer Activities
title_full Biocompatible Alginate Film Crosslinked with Ca(2+) and Zn(2+) Possesses Antibacterial, Antiviral, and Anticancer Activities
title_fullStr Biocompatible Alginate Film Crosslinked with Ca(2+) and Zn(2+) Possesses Antibacterial, Antiviral, and Anticancer Activities
title_full_unstemmed Biocompatible Alginate Film Crosslinked with Ca(2+) and Zn(2+) Possesses Antibacterial, Antiviral, and Anticancer Activities
title_short Biocompatible Alginate Film Crosslinked with Ca(2+) and Zn(2+) Possesses Antibacterial, Antiviral, and Anticancer Activities
title_sort biocompatible alginate film crosslinked with ca(2+) and zn(2+) possesses antibacterial, antiviral, and anticancer activities
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339430/
https://www.ncbi.nlm.nih.gov/pubmed/37457479
http://dx.doi.org/10.1021/acsomega.3c01935
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