Exploring the 5-Substituted 2-Aminobenzothiazole-Based DNA Gyrase B Inhibitors Active against ESKAPE Pathogens

[Image: see text] We present a new series of 2-aminobenzothiazole-based DNA gyrase B inhibitors with promising activity against ESKAPE bacterial pathogens. Based on the binding information extracted from the cocrystal structure of DNA gyrase B inhibitor A, in complex with Escherichia coli GyrB24, we...

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Detalles Bibliográficos
Autores principales: Sterle, Maša, Durcik, Martina, Stevenson, Clare E. M., Henderson, Sara R., Szili, Petra Eva, Czikkely, Marton, Lawson, David M., Maxwell, Anthony, Cahard, Dominique, Kikelj, Danijel, Zidar, Nace, Pal, Csaba, Mašič, Lucija Peterlin, Ilaš, Janez, Tomašič, Tihomir, Cotman, Andrej Emanuel, Zega, Anamarija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339456/
https://www.ncbi.nlm.nih.gov/pubmed/37457471
http://dx.doi.org/10.1021/acsomega.3c01930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339456/
https://www.ncbi.nlm.nih.gov/pubmed/37457471
http://dx.doi.org/10.1021/acsomega.3c01930

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