Transfer of patient’s peripheral blood mononuclear cells (PBMCs) disrupts blood–brain barrier and induces anti-NMDAR encephalitis: a study of novel humanized PBMC mouse model

BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune neuropsychiatric disease. Brain access of anti-NMDAR autoantibody through the blood–brain barrier (BBB) is essential for pathogenesis. Most previous animal models limit the investigation of etiologies of BBB d...

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Detalles Bibliográficos
Autores principales: Shu, Yaqing, Peng, Fuhua, Zhao, Bingchu, Liu, Chunxin, Li, Qihui, Li, Huilu, Wang, Yuge, Jiang, Yanjun, Lu, Tingting, Wang, Qin, Sun, Jian, Feng, Huiyu, Lu, Zhengqi, Liu, Xiaodong, Wang, Jie, Qiu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339507/
https://www.ncbi.nlm.nih.gov/pubmed/37443034
http://dx.doi.org/10.1186/s12974-023-02844-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339507/
https://www.ncbi.nlm.nih.gov/pubmed/37443034
http://dx.doi.org/10.1186/s12974-023-02844-4

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