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Clinical effect of early enteral nutrition support on critically ill neonates with extracorporeal membrane oxygenation

OBJECTIVE: To investigate the feasibility and clinical outcomes of early enteral nutrition (EN) in critically ill neonates supported by extracorporeal membrane oxygenation (ECMO). METHODS: We retrospectively analyzed the clinical data of 16 critically ill neonates who received ECMO support for respi...

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Autores principales: Lin, Ze-Wei, Liu, Ying-Ying, Chen, Xiu-Hua, Zheng, Yi-Rong, Cao, Hua, Chen, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339525/
https://www.ncbi.nlm.nih.gov/pubmed/37442946
http://dx.doi.org/10.1186/s12887-023-04171-2
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author Lin, Ze-Wei
Liu, Ying-Ying
Chen, Xiu-Hua
Zheng, Yi-Rong
Cao, Hua
Chen, Qiang
author_facet Lin, Ze-Wei
Liu, Ying-Ying
Chen, Xiu-Hua
Zheng, Yi-Rong
Cao, Hua
Chen, Qiang
author_sort Lin, Ze-Wei
collection PubMed
description OBJECTIVE: To investigate the feasibility and clinical outcomes of early enteral nutrition (EN) in critically ill neonates supported by extracorporeal membrane oxygenation (ECMO). METHODS: We retrospectively analyzed the clinical data of 16 critically ill neonates who received ECMO support for respiratory and circulatory failure from July 2021 to December 2022 at our center. The patients were divided into two groups: the early EN group (< 24 h) and the late EN group (> 24 h). The related clinical and nutrition-related indicators between the groups were compared. RESULTS: There was a significant difference in the time from ECMO treatment to the start of EN between the early EN group (9 patients, 56.2%) and the late EN group (7 patients, 43.8%) (P < 0.05). However, there were no significant differences in ECMO duration, hospitalization time, vasoactive-inotropic score (VIS), intestinal oxygen saturation, or routine stool occult blood (OB) test between the two groups (all P > 0.05). The incidence of complications such as intestinal obstruction, abdominal distension, diarrhea, and necrotizing enterocolitis (NEC) was slightly lower in the early EN group, but the differences were not statistically significant (all P > 0.05). The early EN group had a shorter time [3.6 (3.5, 5) vs. 7.5 (5.9, 8.5) d] to reach full gastrointestinal nutrition compared to the late EN group (P < 0.05). CONCLUSION: Providing early nutritional support through enteral feeding to critically ill neonates receiving ECMO treatment is both safe and practical, but close monitoring of clinical and nutritional indicators is essential.
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spelling pubmed-103395252023-07-14 Clinical effect of early enteral nutrition support on critically ill neonates with extracorporeal membrane oxygenation Lin, Ze-Wei Liu, Ying-Ying Chen, Xiu-Hua Zheng, Yi-Rong Cao, Hua Chen, Qiang BMC Pediatr Research OBJECTIVE: To investigate the feasibility and clinical outcomes of early enteral nutrition (EN) in critically ill neonates supported by extracorporeal membrane oxygenation (ECMO). METHODS: We retrospectively analyzed the clinical data of 16 critically ill neonates who received ECMO support for respiratory and circulatory failure from July 2021 to December 2022 at our center. The patients were divided into two groups: the early EN group (< 24 h) and the late EN group (> 24 h). The related clinical and nutrition-related indicators between the groups were compared. RESULTS: There was a significant difference in the time from ECMO treatment to the start of EN between the early EN group (9 patients, 56.2%) and the late EN group (7 patients, 43.8%) (P < 0.05). However, there were no significant differences in ECMO duration, hospitalization time, vasoactive-inotropic score (VIS), intestinal oxygen saturation, or routine stool occult blood (OB) test between the two groups (all P > 0.05). The incidence of complications such as intestinal obstruction, abdominal distension, diarrhea, and necrotizing enterocolitis (NEC) was slightly lower in the early EN group, but the differences were not statistically significant (all P > 0.05). The early EN group had a shorter time [3.6 (3.5, 5) vs. 7.5 (5.9, 8.5) d] to reach full gastrointestinal nutrition compared to the late EN group (P < 0.05). CONCLUSION: Providing early nutritional support through enteral feeding to critically ill neonates receiving ECMO treatment is both safe and practical, but close monitoring of clinical and nutritional indicators is essential. BioMed Central 2023-07-13 /pmc/articles/PMC10339525/ /pubmed/37442946 http://dx.doi.org/10.1186/s12887-023-04171-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Lin, Ze-Wei
Liu, Ying-Ying
Chen, Xiu-Hua
Zheng, Yi-Rong
Cao, Hua
Chen, Qiang
Clinical effect of early enteral nutrition support on critically ill neonates with extracorporeal membrane oxygenation
title Clinical effect of early enteral nutrition support on critically ill neonates with extracorporeal membrane oxygenation
title_full Clinical effect of early enteral nutrition support on critically ill neonates with extracorporeal membrane oxygenation
title_fullStr Clinical effect of early enteral nutrition support on critically ill neonates with extracorporeal membrane oxygenation
title_full_unstemmed Clinical effect of early enteral nutrition support on critically ill neonates with extracorporeal membrane oxygenation
title_short Clinical effect of early enteral nutrition support on critically ill neonates with extracorporeal membrane oxygenation
title_sort clinical effect of early enteral nutrition support on critically ill neonates with extracorporeal membrane oxygenation
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339525/
https://www.ncbi.nlm.nih.gov/pubmed/37442946
http://dx.doi.org/10.1186/s12887-023-04171-2
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