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Adenosine metabolized from extracellular ATP ameliorates organ injury by triggering A(2B)R signaling

BACKGROUND: Trauma and a subsequent hemorrhagic shock (T/HS) result in insufficient oxygen delivery to tissues and multiple organ failure. Extracellular adenosine, which is a product of the extracellular degradation of adenosine 5’ triphosphate (ATP) by the membrane-embedded enzymes CD39 and CD73, i...

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Detalles Bibliográficos
Autores principales:	Kelestemur, Taha, Németh, Zoltán H., Pacher, Pal, Beesley, Jennet, Robson, Simon C., Eltzschig, Holger K., Haskó, György
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339538/ https://www.ncbi.nlm.nih.gov/pubmed/37438813 http://dx.doi.org/10.1186/s12931-023-02486-3

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