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Association of air pollution with postmenopausal breast cancer risk in UK Biobank

BACKGROUND: We investigated the association of several air pollution measures with postmenopausal breast cancer (BCa) risk. METHODS: This study included 155,235 postmenopausal women (of which 6146 with BCa) from UK Biobank. Cancer diagnoses were ascertained through the linkage to the UK National Hea...

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Autores principales: Smotherman, Carmen, Sprague, Brian, Datta, Susmita, Braithwaite, Dejana, Qin, Huaizhen, Yaghjyan, Lusine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339564/
https://www.ncbi.nlm.nih.gov/pubmed/37443054
http://dx.doi.org/10.1186/s13058-023-01681-w
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author Smotherman, Carmen
Sprague, Brian
Datta, Susmita
Braithwaite, Dejana
Qin, Huaizhen
Yaghjyan, Lusine
author_facet Smotherman, Carmen
Sprague, Brian
Datta, Susmita
Braithwaite, Dejana
Qin, Huaizhen
Yaghjyan, Lusine
author_sort Smotherman, Carmen
collection PubMed
description BACKGROUND: We investigated the association of several air pollution measures with postmenopausal breast cancer (BCa) risk. METHODS: This study included 155,235 postmenopausal women (of which 6146 with BCa) from UK Biobank. Cancer diagnoses were ascertained through the linkage to the UK National Health Service Central Registers. Annual exposure averages were available from 2005, 2006, 2007, and 2010 for NO(2), from 2007 and 2010 for PM(10), and from 2010 for PM(2.5), NO(X), PM(2.5–10) and PM(2.5) absorbance. Information on BCa risk factors was collected at baseline. Cox proportional hazards regression was used to evaluate the associations of year-specific and cumulative average exposures with BCa risk, overall and with 2-year exposure lag, while adjusting for BCa risk factors. RESULTS: PM(10) in 2007 and cumulative average PM(10) were positively associated with BCa risk (2007 PM(10): Hazard ratio [HR] per 10 µg/m(3) = 1.18, 95% CI 1.08, 1.29; cumulative average PM(10): HR per 10 µg/m(3) = 1.99, 95% CI 1.75, 2.27). Compared to women with low exposure, women with higher 2007 PM(10) and cumulative average PM(10) had greater BCa risk (4th vs. 1st quartile HR = 1.15, 95% CI 1.07, 1.24, p-trend = 0.001 and HR = 1.35, 95% CI 1.25, 1.44, p-trend < 0.0001, respectively). No significant associations were found for any other exposure measures. In the analysis with 2-year exposure lag, both 2007 PM 10 and cumulative average PM10 were positively associated with BCa risk (4th vs. 1st quartile HR = 1.19, 95% CI 1.10, 1.28 and HR = 1.29, 95% CI 1.19, 1.39, respectively). CONCLUSION: Our findings suggest a positive association of 2007 PM(10) and cumulative average PM(10) with postmenopausal BCa risk. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13058-023-01681-w.
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spelling pubmed-103395642023-07-14 Association of air pollution with postmenopausal breast cancer risk in UK Biobank Smotherman, Carmen Sprague, Brian Datta, Susmita Braithwaite, Dejana Qin, Huaizhen Yaghjyan, Lusine Breast Cancer Res Research BACKGROUND: We investigated the association of several air pollution measures with postmenopausal breast cancer (BCa) risk. METHODS: This study included 155,235 postmenopausal women (of which 6146 with BCa) from UK Biobank. Cancer diagnoses were ascertained through the linkage to the UK National Health Service Central Registers. Annual exposure averages were available from 2005, 2006, 2007, and 2010 for NO(2), from 2007 and 2010 for PM(10), and from 2010 for PM(2.5), NO(X), PM(2.5–10) and PM(2.5) absorbance. Information on BCa risk factors was collected at baseline. Cox proportional hazards regression was used to evaluate the associations of year-specific and cumulative average exposures with BCa risk, overall and with 2-year exposure lag, while adjusting for BCa risk factors. RESULTS: PM(10) in 2007 and cumulative average PM(10) were positively associated with BCa risk (2007 PM(10): Hazard ratio [HR] per 10 µg/m(3) = 1.18, 95% CI 1.08, 1.29; cumulative average PM(10): HR per 10 µg/m(3) = 1.99, 95% CI 1.75, 2.27). Compared to women with low exposure, women with higher 2007 PM(10) and cumulative average PM(10) had greater BCa risk (4th vs. 1st quartile HR = 1.15, 95% CI 1.07, 1.24, p-trend = 0.001 and HR = 1.35, 95% CI 1.25, 1.44, p-trend < 0.0001, respectively). No significant associations were found for any other exposure measures. In the analysis with 2-year exposure lag, both 2007 PM 10 and cumulative average PM10 were positively associated with BCa risk (4th vs. 1st quartile HR = 1.19, 95% CI 1.10, 1.28 and HR = 1.29, 95% CI 1.19, 1.39, respectively). CONCLUSION: Our findings suggest a positive association of 2007 PM(10) and cumulative average PM(10) with postmenopausal BCa risk. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13058-023-01681-w. BioMed Central 2023-07-13 2023 /pmc/articles/PMC10339564/ /pubmed/37443054 http://dx.doi.org/10.1186/s13058-023-01681-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Smotherman, Carmen
Sprague, Brian
Datta, Susmita
Braithwaite, Dejana
Qin, Huaizhen
Yaghjyan, Lusine
Association of air pollution with postmenopausal breast cancer risk in UK Biobank
title Association of air pollution with postmenopausal breast cancer risk in UK Biobank
title_full Association of air pollution with postmenopausal breast cancer risk in UK Biobank
title_fullStr Association of air pollution with postmenopausal breast cancer risk in UK Biobank
title_full_unstemmed Association of air pollution with postmenopausal breast cancer risk in UK Biobank
title_short Association of air pollution with postmenopausal breast cancer risk in UK Biobank
title_sort association of air pollution with postmenopausal breast cancer risk in uk biobank
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339564/
https://www.ncbi.nlm.nih.gov/pubmed/37443054
http://dx.doi.org/10.1186/s13058-023-01681-w
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