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ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease

BACKGROUND: Nuclear acetyl-CoA pools govern histone acetylation that controls synaptic plasticity and contributes to cognitive deterioration in patients with Alzheimer’s disease (AD). Nuclear acetyl-CoA pools are generated partially from local acetate that is metabolized by acetyl-CoA synthetase 2 (...

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Detalles Bibliográficos
Autores principales:	Lin, Yingbin, Lin, Anlan, Cai, Lili, Huang, Weibin, Yan, Shanzhi, Wei, Yuanxiang, Ruan, Xinglin, Fang, Wenting, Dai, Xiaoman, Cheng, Jinbo, Zhang, Jie, Chen, Wanjin, Ye, Qinyong, Chen, Xiaochun, Zhang, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339567/ https://www.ncbi.nlm.nih.gov/pubmed/37438762 http://dx.doi.org/10.1186/s13024-023-00625-4

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