Cargando…

Changes in the patterns of respiratory support and incidence of bronchopulmonary dysplasia; a single center experience

BACKGROUND: With the advances in neonatal intensive care, the survival rate of extremely preterm infants is increasing. However, bronchopulmonary dysplasia (BPD) remains a major cause of morbidity among infants in this group. This study examined the changes in respiratory support modalities, specifi...

Descripción completa

Detalles Bibliográficos
Autores principales: Algarni, Saleh S., Ali, Kamal, Alsaif, Saif, Aljuaid, Nemer, Alzahrani, Raghad, Albassam, Maha, Alanazi, Rawan, Alqueflie, Dana, Almutairi, Maather, Alfrijan, Hessah, Alanazi, Ahmad, Ghazwani, Abadi, Alshareedah, Saad, Alotaibi, Tareq F, Alqahtani, Mohammed M, Aljohani, Hassan, Ismaeil, Taha T, Alwadeai, Khalid S, Siraj, Rayan A, Alsaif, Abdurahman, Asiri, Sabreen, Halabi, Shaimaa, Alanazi, Abdullah M M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339611/
https://www.ncbi.nlm.nih.gov/pubmed/37442954
http://dx.doi.org/10.1186/s12887-023-04176-x
_version_ 1785071884865372160
author Algarni, Saleh S.
Ali, Kamal
Alsaif, Saif
Aljuaid, Nemer
Alzahrani, Raghad
Albassam, Maha
Alanazi, Rawan
Alqueflie, Dana
Almutairi, Maather
Alfrijan, Hessah
Alanazi, Ahmad
Ghazwani, Abadi
Alshareedah, Saad
Alotaibi, Tareq F
Alqahtani, Mohammed M
Aljohani, Hassan
Ismaeil, Taha T
Alwadeai, Khalid S
Siraj, Rayan A
Alsaif, Abdurahman
Asiri, Sabreen
Halabi, Shaimaa
Alanazi, Abdullah M M
author_facet Algarni, Saleh S.
Ali, Kamal
Alsaif, Saif
Aljuaid, Nemer
Alzahrani, Raghad
Albassam, Maha
Alanazi, Rawan
Alqueflie, Dana
Almutairi, Maather
Alfrijan, Hessah
Alanazi, Ahmad
Ghazwani, Abadi
Alshareedah, Saad
Alotaibi, Tareq F
Alqahtani, Mohammed M
Aljohani, Hassan
Ismaeil, Taha T
Alwadeai, Khalid S
Siraj, Rayan A
Alsaif, Abdurahman
Asiri, Sabreen
Halabi, Shaimaa
Alanazi, Abdullah M M
author_sort Algarni, Saleh S.
collection PubMed
description BACKGROUND: With the advances in neonatal intensive care, the survival rate of extremely preterm infants is increasing. However, bronchopulmonary dysplasia (BPD) remains a major cause of morbidity among infants in this group. This study examined the changes in respiratory support modalities, specifically heated humidified high-flow nasal cannula (HHHFNC), and their association with BPD incidence among preterm infants born at < 29 weeks of gestation. METHOD: This population-based retrospective cohort study included infants born at < 29 weeks of gestation between 2016 and 2020. Data regarding the use and duration of respiratory support modalities were obtained, including mechanical ventilation, continuous positive airway pressure, HHHFNC, and low-flow oxygen therapy. Additionally, the incidence of BPD was determined in the included infants. Trend analysis for each respiratory support modality and BPD incidence rate was performed to define the temporal changes associated with changes in BPD rates. In addition, a logistic regression model was developed to identify the association between BPD and severity grade using HHHFNC. RESULTS: Three Hundred and sixteen infants were included in this study. The use and duration of HHHFNC therapy increased during the study period. Throughout the study period, the overall incidence of BPD was 49%, with no significant trends. The BPD rate was significantly higher in the infants who received HHHFNC than in those who did not (52% vs. 39%, P = 0.03). Analysis of BPD severity grades showed that both grade 1 BPD (34% vs. 21%, P = 0.03) and grade 2 BPD (12% vs. 1%, P < 0.01) were significantly more common among infants who received HHHFNC than among those who did not. In contrast, the incidence of grade 3 BPD was lower in infants who received HHFNC (6% vs. 17%, P < 0.01). The duration in days of HHHFNC was found to significantly predict BPD incidence (OR 1.04 [95%CI: 1.01–1.06], P < 0.01) after adjusting for confounding variables. CONCLUSION: The use of HHHFNC in extremely preterm infants born at < 29 weeks of gestation is increasing. There was a significant association between the duration of HHHFNC therapy and the development of BPD in extremely preterm infants born at < 29 weeks of gestation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-023-04176-x.
format Online
Article
Text
id pubmed-10339611
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-103396112023-07-14 Changes in the patterns of respiratory support and incidence of bronchopulmonary dysplasia; a single center experience Algarni, Saleh S. Ali, Kamal Alsaif, Saif Aljuaid, Nemer Alzahrani, Raghad Albassam, Maha Alanazi, Rawan Alqueflie, Dana Almutairi, Maather Alfrijan, Hessah Alanazi, Ahmad Ghazwani, Abadi Alshareedah, Saad Alotaibi, Tareq F Alqahtani, Mohammed M Aljohani, Hassan Ismaeil, Taha T Alwadeai, Khalid S Siraj, Rayan A Alsaif, Abdurahman Asiri, Sabreen Halabi, Shaimaa Alanazi, Abdullah M M BMC Pediatr Research BACKGROUND: With the advances in neonatal intensive care, the survival rate of extremely preterm infants is increasing. However, bronchopulmonary dysplasia (BPD) remains a major cause of morbidity among infants in this group. This study examined the changes in respiratory support modalities, specifically heated humidified high-flow nasal cannula (HHHFNC), and their association with BPD incidence among preterm infants born at < 29 weeks of gestation. METHOD: This population-based retrospective cohort study included infants born at < 29 weeks of gestation between 2016 and 2020. Data regarding the use and duration of respiratory support modalities were obtained, including mechanical ventilation, continuous positive airway pressure, HHHFNC, and low-flow oxygen therapy. Additionally, the incidence of BPD was determined in the included infants. Trend analysis for each respiratory support modality and BPD incidence rate was performed to define the temporal changes associated with changes in BPD rates. In addition, a logistic regression model was developed to identify the association between BPD and severity grade using HHHFNC. RESULTS: Three Hundred and sixteen infants were included in this study. The use and duration of HHHFNC therapy increased during the study period. Throughout the study period, the overall incidence of BPD was 49%, with no significant trends. The BPD rate was significantly higher in the infants who received HHHFNC than in those who did not (52% vs. 39%, P = 0.03). Analysis of BPD severity grades showed that both grade 1 BPD (34% vs. 21%, P = 0.03) and grade 2 BPD (12% vs. 1%, P < 0.01) were significantly more common among infants who received HHHFNC than among those who did not. In contrast, the incidence of grade 3 BPD was lower in infants who received HHFNC (6% vs. 17%, P < 0.01). The duration in days of HHHFNC was found to significantly predict BPD incidence (OR 1.04 [95%CI: 1.01–1.06], P < 0.01) after adjusting for confounding variables. CONCLUSION: The use of HHHFNC in extremely preterm infants born at < 29 weeks of gestation is increasing. There was a significant association between the duration of HHHFNC therapy and the development of BPD in extremely preterm infants born at < 29 weeks of gestation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-023-04176-x. BioMed Central 2023-07-13 /pmc/articles/PMC10339611/ /pubmed/37442954 http://dx.doi.org/10.1186/s12887-023-04176-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Algarni, Saleh S.
Ali, Kamal
Alsaif, Saif
Aljuaid, Nemer
Alzahrani, Raghad
Albassam, Maha
Alanazi, Rawan
Alqueflie, Dana
Almutairi, Maather
Alfrijan, Hessah
Alanazi, Ahmad
Ghazwani, Abadi
Alshareedah, Saad
Alotaibi, Tareq F
Alqahtani, Mohammed M
Aljohani, Hassan
Ismaeil, Taha T
Alwadeai, Khalid S
Siraj, Rayan A
Alsaif, Abdurahman
Asiri, Sabreen
Halabi, Shaimaa
Alanazi, Abdullah M M
Changes in the patterns of respiratory support and incidence of bronchopulmonary dysplasia; a single center experience
title Changes in the patterns of respiratory support and incidence of bronchopulmonary dysplasia; a single center experience
title_full Changes in the patterns of respiratory support and incidence of bronchopulmonary dysplasia; a single center experience
title_fullStr Changes in the patterns of respiratory support and incidence of bronchopulmonary dysplasia; a single center experience
title_full_unstemmed Changes in the patterns of respiratory support and incidence of bronchopulmonary dysplasia; a single center experience
title_short Changes in the patterns of respiratory support and incidence of bronchopulmonary dysplasia; a single center experience
title_sort changes in the patterns of respiratory support and incidence of bronchopulmonary dysplasia; a single center experience
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339611/
https://www.ncbi.nlm.nih.gov/pubmed/37442954
http://dx.doi.org/10.1186/s12887-023-04176-x
work_keys_str_mv AT algarnisalehs changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT alikamal changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT alsaifsaif changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT aljuaidnemer changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT alzahraniraghad changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT albassammaha changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT alanazirawan changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT alquefliedana changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT almutairimaather changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT alfrijanhessah changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT alanaziahmad changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT ghazwaniabadi changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT alshareedahsaad changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT alotaibitareqf changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT alqahtanimohammedm changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT aljohanihassan changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT ismaeiltahat changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT alwadeaikhalids changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT sirajrayana changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT alsaifabdurahman changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT asirisabreen changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT halabishaimaa changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience
AT alanaziabdullahmm changesinthepatternsofrespiratorysupportandincidenceofbronchopulmonarydysplasiaasinglecenterexperience