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Model‐informed approach to support pediatric dosing for the pan‐PI3K inhibitor copanlisib in children and adolescents with relapsed/refractory solid tumors

Copanlisib is an intravenously administered phosphatidylinositol 3‐kinase (PI3K) inhibitor which was investigated in pediatric patients with relapsed/refractory solid tumors. A model‐informed approach was undertaken to support and confirm an empirically selected starting dose of 28 mg/m(2) for pedia...

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Detalles Bibliográficos
Autores principales:	Morcos, Peter N., Schlender, Jan, Burghaus, Rolf, Moss, Jonathan, Lloyd, Adam, Childs, Barrett H., Macy, Margaret E., Reid, Joel M., Chung, John, Garmann, Dirk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339701/ https://www.ncbi.nlm.nih.gov/pubmed/37042099 http://dx.doi.org/10.1111/cts.13523

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