A linked physiologically based pharmacokinetic model for hydroxychloroquine and metabolite desethylhydroxychloroquine in SARS‐CoV‐2(−)/(+) populations

Hydroxychloroquine (HCQ) is Food and Drug Administration (FDA)‐approved for malaria, systemic and chronic discoid lupus erythematosus, and rheumatoid arthritis. Because HCQ has a proposed multimodal mechanism of action and a well‐established safety profile, it is often investigated as a repurposed t...

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Detalles Bibliográficos
Autores principales: Steinbronn, Claire, Chhonker, Yashpal S., Stewart, Jenell, Leingang, Hannah, Heller, Kate B., Krows, Meighan L., Paasche‐Orlow, Michael, Bershteyn, Anna, Stankiewicz Karita, Helen C., Agrawal, Vaidehi, Laufer, Miriam, Landovitz, Raphael, Wener, Mark, Murry, Daryl J., Johnston, Christine, Barnabas, Ruanne V., Arnold, Samuel L. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339702/
https://www.ncbi.nlm.nih.gov/pubmed/37118968
http://dx.doi.org/10.1111/cts.13527

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