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Limitations of fexofenadine limited sampling strategy using plasma concentrations and partial area under the concentration-time curve to estimate transporter activity in healthy adults

Objective: Fexofenadine is a probe drug used to phenotype P-glycoprotein (P-gp) and organic anion transporting polypeptide (OATP) 1B1/3 activities. This study evaluated a limited sampling strategy using plasma concentrations and/or partial area under the concentration versus time curves (AUCs) to es...

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Detalles Bibliográficos
Autores principales:	Liyanage, Marlon, Blaquera, Chelsea L., Piscitelli, Joseph, Penzak, Scott R., Nolin, Thomas D., Paine, Mary F., Ma, Joseph D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dustri-Verlag Dr. Karl Feistle 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339714/ https://www.ncbi.nlm.nih.gov/pubmed/37042268 http://dx.doi.org/10.5414/CP204380

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