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The functions and roles of C2H2 zinc finger proteins in hepatocellular carcinoma

C2H2 zinc finger (C2H2-ZF) proteins are the majority group of human transcription factors and they have many different molecular functions through different combinations of zinc finger domains. Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors and the main reason for cance...

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Detalles Bibliográficos
Autores principales: Li, Qinguo, Tan, Guoqian, Wu, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339807/
https://www.ncbi.nlm.nih.gov/pubmed/37457025
http://dx.doi.org/10.3389/fphys.2023.1129889
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author Li, Qinguo
Tan, Guoqian
Wu, Fan
author_facet Li, Qinguo
Tan, Guoqian
Wu, Fan
author_sort Li, Qinguo
collection PubMed
description C2H2 zinc finger (C2H2-ZF) proteins are the majority group of human transcription factors and they have many different molecular functions through different combinations of zinc finger domains. Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors and the main reason for cancer-related deaths worldwide. More and more findings support the abnormal expression of C2H2-ZF protein in the onset and progression of HCC. The C2H2-ZF proteins are involved in various biological functions in HCC, such as EMT, stemness maintenance, metabolic reprogramming, cell proliferation and growth, apoptosis, and genomic integrity. The study of anti-tumor drug resistance also highlights the pivotal roles of C2H2-ZF proteins at the intersection of biological functions (EMT, stemness maintenance, autophagy)and chemoresistance in HCC. The involvement of C2H2-ZF protein found recently in regulating different molecules, signal pathways and pathophysiological activities indicate these proteins as the possible therapeutic targets, and diagnostic or prognostic biomarkers for HCC.
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spelling pubmed-103398072023-07-14 The functions and roles of C2H2 zinc finger proteins in hepatocellular carcinoma Li, Qinguo Tan, Guoqian Wu, Fan Front Physiol Physiology C2H2 zinc finger (C2H2-ZF) proteins are the majority group of human transcription factors and they have many different molecular functions through different combinations of zinc finger domains. Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors and the main reason for cancer-related deaths worldwide. More and more findings support the abnormal expression of C2H2-ZF protein in the onset and progression of HCC. The C2H2-ZF proteins are involved in various biological functions in HCC, such as EMT, stemness maintenance, metabolic reprogramming, cell proliferation and growth, apoptosis, and genomic integrity. The study of anti-tumor drug resistance also highlights the pivotal roles of C2H2-ZF proteins at the intersection of biological functions (EMT, stemness maintenance, autophagy)and chemoresistance in HCC. The involvement of C2H2-ZF protein found recently in regulating different molecules, signal pathways and pathophysiological activities indicate these proteins as the possible therapeutic targets, and diagnostic or prognostic biomarkers for HCC. Frontiers Media S.A. 2023-06-29 /pmc/articles/PMC10339807/ /pubmed/37457025 http://dx.doi.org/10.3389/fphys.2023.1129889 Text en Copyright © 2023 Li, Tan and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Li, Qinguo
Tan, Guoqian
Wu, Fan
The functions and roles of C2H2 zinc finger proteins in hepatocellular carcinoma
title The functions and roles of C2H2 zinc finger proteins in hepatocellular carcinoma
title_full The functions and roles of C2H2 zinc finger proteins in hepatocellular carcinoma
title_fullStr The functions and roles of C2H2 zinc finger proteins in hepatocellular carcinoma
title_full_unstemmed The functions and roles of C2H2 zinc finger proteins in hepatocellular carcinoma
title_short The functions and roles of C2H2 zinc finger proteins in hepatocellular carcinoma
title_sort functions and roles of c2h2 zinc finger proteins in hepatocellular carcinoma
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339807/
https://www.ncbi.nlm.nih.gov/pubmed/37457025
http://dx.doi.org/10.3389/fphys.2023.1129889
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