A Shared Pathogenic Mechanism for Valproic Acid and SHROOM3 Knockout in a Brain Organoid Model of Neural Tube Defects

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Neural tube defects (NTDs), including anencephaly and spina bifida, are common major malformations of fetal development resulting from incomplete closure of the neural tube. These conditions lead to either universal death (anencephaly) or severe lifelong complications (spina bifida). Despite hundred...

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Detalles Bibliográficos
Autores principales: Takla, Taylor N., Luo, Jinghui, Sudyk, Roksolana, Huang, Joy, Walker, John Clayton, Vora, Neeta L., Sexton, Jonathan Z., Parent, Jack M., Tidball, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340169/
https://www.ncbi.nlm.nih.gov/pubmed/37443734
http://dx.doi.org/10.3390/cells12131697

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