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Could Endothelin-1 Be a Promising Neurohormonal Biomarker in Acute Heart Failure?
Acute heart failure (AHF) is a life-threatening condition with high morbidity and mortality. Even though this pathology has been extensively researched, there are still challenges in establishing an accurate and early diagnosis, determining the long- and short-term prognosis and choosing a targeted...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340204/ https://www.ncbi.nlm.nih.gov/pubmed/37443671 http://dx.doi.org/10.3390/diagnostics13132277 |
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author | Dmour, Bianca-Ana Costache, Alexandru Dan Dmour, Awad Huzum, Bogdan Duca, Ștefania Teodora Chetran, Adriana Miftode, Radu Ștefan Afrăsânie, Irina Tuchiluș, Cristina Cianga, Corina Maria Botnariu, Gina Șerban, Lăcrămioara Ionela Ciocoiu, Manuela Bădescu, Codruța Minerva Costache, Irina Iuliana |
author_facet | Dmour, Bianca-Ana Costache, Alexandru Dan Dmour, Awad Huzum, Bogdan Duca, Ștefania Teodora Chetran, Adriana Miftode, Radu Ștefan Afrăsânie, Irina Tuchiluș, Cristina Cianga, Corina Maria Botnariu, Gina Șerban, Lăcrămioara Ionela Ciocoiu, Manuela Bădescu, Codruța Minerva Costache, Irina Iuliana |
author_sort | Dmour, Bianca-Ana |
collection | PubMed |
description | Acute heart failure (AHF) is a life-threatening condition with high morbidity and mortality. Even though this pathology has been extensively researched, there are still challenges in establishing an accurate and early diagnosis, determining the long- and short-term prognosis and choosing a targeted therapeutic strategy. The use of reliable biomarkers to support clinical judgment has been shown to improve the management of AHF patients. Despite a large pool of interesting candidate biomarkers, endothelin-1 (ET-1) appears to be involved in multiple aspects of AHF pathogenesis that include neurohormonal activation, cardiac remodeling, endothelial dysfunction, inflammation, atherosclerosis and alteration of the renal function. Since its discovery, numerous studies have shown that the level of ET-1 is associated with the severity of symptoms and cardiac dysfunction in this pathology. The purpose of this paper is to review the existing information on ET-1 and answer the question of whether this neurohormone could be a promising biomarker in AHF. |
format | Online Article Text |
id | pubmed-10340204 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103402042023-07-14 Could Endothelin-1 Be a Promising Neurohormonal Biomarker in Acute Heart Failure? Dmour, Bianca-Ana Costache, Alexandru Dan Dmour, Awad Huzum, Bogdan Duca, Ștefania Teodora Chetran, Adriana Miftode, Radu Ștefan Afrăsânie, Irina Tuchiluș, Cristina Cianga, Corina Maria Botnariu, Gina Șerban, Lăcrămioara Ionela Ciocoiu, Manuela Bădescu, Codruța Minerva Costache, Irina Iuliana Diagnostics (Basel) Review Acute heart failure (AHF) is a life-threatening condition with high morbidity and mortality. Even though this pathology has been extensively researched, there are still challenges in establishing an accurate and early diagnosis, determining the long- and short-term prognosis and choosing a targeted therapeutic strategy. The use of reliable biomarkers to support clinical judgment has been shown to improve the management of AHF patients. Despite a large pool of interesting candidate biomarkers, endothelin-1 (ET-1) appears to be involved in multiple aspects of AHF pathogenesis that include neurohormonal activation, cardiac remodeling, endothelial dysfunction, inflammation, atherosclerosis and alteration of the renal function. Since its discovery, numerous studies have shown that the level of ET-1 is associated with the severity of symptoms and cardiac dysfunction in this pathology. The purpose of this paper is to review the existing information on ET-1 and answer the question of whether this neurohormone could be a promising biomarker in AHF. MDPI 2023-07-05 /pmc/articles/PMC10340204/ /pubmed/37443671 http://dx.doi.org/10.3390/diagnostics13132277 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dmour, Bianca-Ana Costache, Alexandru Dan Dmour, Awad Huzum, Bogdan Duca, Ștefania Teodora Chetran, Adriana Miftode, Radu Ștefan Afrăsânie, Irina Tuchiluș, Cristina Cianga, Corina Maria Botnariu, Gina Șerban, Lăcrămioara Ionela Ciocoiu, Manuela Bădescu, Codruța Minerva Costache, Irina Iuliana Could Endothelin-1 Be a Promising Neurohormonal Biomarker in Acute Heart Failure? |
title | Could Endothelin-1 Be a Promising Neurohormonal Biomarker in Acute Heart Failure? |
title_full | Could Endothelin-1 Be a Promising Neurohormonal Biomarker in Acute Heart Failure? |
title_fullStr | Could Endothelin-1 Be a Promising Neurohormonal Biomarker in Acute Heart Failure? |
title_full_unstemmed | Could Endothelin-1 Be a Promising Neurohormonal Biomarker in Acute Heart Failure? |
title_short | Could Endothelin-1 Be a Promising Neurohormonal Biomarker in Acute Heart Failure? |
title_sort | could endothelin-1 be a promising neurohormonal biomarker in acute heart failure? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340204/ https://www.ncbi.nlm.nih.gov/pubmed/37443671 http://dx.doi.org/10.3390/diagnostics13132277 |
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