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Inflammasomes: Mechanisms of Action and Involvement in Human Diseases
Inflammasome complexes and their integral receptor proteins have essential roles in regulating the innate immune response and inflammation at the post-translational level. Yet despite their protective role, aberrant activation of inflammasome proteins and gain of function mutations in inflammasome c...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340308/ https://www.ncbi.nlm.nih.gov/pubmed/37443800 http://dx.doi.org/10.3390/cells12131766 |
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author | Bulté, Dimitri Rigamonti, Chiara Romano, Alessandro Mortellaro, Alessandra |
author_facet | Bulté, Dimitri Rigamonti, Chiara Romano, Alessandro Mortellaro, Alessandra |
author_sort | Bulté, Dimitri |
collection | PubMed |
description | Inflammasome complexes and their integral receptor proteins have essential roles in regulating the innate immune response and inflammation at the post-translational level. Yet despite their protective role, aberrant activation of inflammasome proteins and gain of function mutations in inflammasome component genes seem to contribute to the development and progression of human autoimmune and autoinflammatory diseases. In the past decade, our understanding of inflammasome biology and activation mechanisms has greatly progressed. We therefore provide an up-to-date overview of the various inflammasomes and their known mechanisms of action. In addition, we highlight the involvement of various inflammasomes and their pathogenic mechanisms in common autoinflammatory, autoimmune and neurodegenerative diseases, including atherosclerosis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. We conclude by speculating on the future avenues of research needed to better understand the roles of inflammasomes in health and disease. |
format | Online Article Text |
id | pubmed-10340308 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103403082023-07-14 Inflammasomes: Mechanisms of Action and Involvement in Human Diseases Bulté, Dimitri Rigamonti, Chiara Romano, Alessandro Mortellaro, Alessandra Cells Review Inflammasome complexes and their integral receptor proteins have essential roles in regulating the innate immune response and inflammation at the post-translational level. Yet despite their protective role, aberrant activation of inflammasome proteins and gain of function mutations in inflammasome component genes seem to contribute to the development and progression of human autoimmune and autoinflammatory diseases. In the past decade, our understanding of inflammasome biology and activation mechanisms has greatly progressed. We therefore provide an up-to-date overview of the various inflammasomes and their known mechanisms of action. In addition, we highlight the involvement of various inflammasomes and their pathogenic mechanisms in common autoinflammatory, autoimmune and neurodegenerative diseases, including atherosclerosis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. We conclude by speculating on the future avenues of research needed to better understand the roles of inflammasomes in health and disease. MDPI 2023-07-03 /pmc/articles/PMC10340308/ /pubmed/37443800 http://dx.doi.org/10.3390/cells12131766 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bulté, Dimitri Rigamonti, Chiara Romano, Alessandro Mortellaro, Alessandra Inflammasomes: Mechanisms of Action and Involvement in Human Diseases |
title | Inflammasomes: Mechanisms of Action and Involvement in Human Diseases |
title_full | Inflammasomes: Mechanisms of Action and Involvement in Human Diseases |
title_fullStr | Inflammasomes: Mechanisms of Action and Involvement in Human Diseases |
title_full_unstemmed | Inflammasomes: Mechanisms of Action and Involvement in Human Diseases |
title_short | Inflammasomes: Mechanisms of Action and Involvement in Human Diseases |
title_sort | inflammasomes: mechanisms of action and involvement in human diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340308/ https://www.ncbi.nlm.nih.gov/pubmed/37443800 http://dx.doi.org/10.3390/cells12131766 |
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