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Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond

Actin binding proteins are of crucial importance for the spatiotemporal regulation of actin cytoskeletal dynamics, thereby mediating a tremendous range of cellular processes. Since their initial discovery more than 30 years ago, the enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) family has...

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Autores principales: Benz, Peter M., Frömel, Timo, Laban, Hebatullah, Zink, Joana, Ulrich, Lea, Groneberg, Dieter, Boon, Reinier A., Poley, Philip, Renne, Thomas, de Wit, Cor, Fleming, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340426/
https://www.ncbi.nlm.nih.gov/pubmed/37443774
http://dx.doi.org/10.3390/cells12131740
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author Benz, Peter M.
Frömel, Timo
Laban, Hebatullah
Zink, Joana
Ulrich, Lea
Groneberg, Dieter
Boon, Reinier A.
Poley, Philip
Renne, Thomas
de Wit, Cor
Fleming, Ingrid
author_facet Benz, Peter M.
Frömel, Timo
Laban, Hebatullah
Zink, Joana
Ulrich, Lea
Groneberg, Dieter
Boon, Reinier A.
Poley, Philip
Renne, Thomas
de Wit, Cor
Fleming, Ingrid
author_sort Benz, Peter M.
collection PubMed
description Actin binding proteins are of crucial importance for the spatiotemporal regulation of actin cytoskeletal dynamics, thereby mediating a tremendous range of cellular processes. Since their initial discovery more than 30 years ago, the enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) family has evolved as one of the most fascinating and versatile family of actin regulating proteins. The proteins directly enhance actin filament assembly, but they also organize higher order actin networks and link kinase signaling pathways to actin filament assembly. Thereby, Ena/VASP proteins regulate dynamic cellular processes ranging from membrane protrusions and trafficking, and cell-cell and cell-matrix adhesions, to the generation of mechanical tension and contractile force. Important insights have been gained into the physiological functions of Ena/VASP proteins in platelets, leukocytes, endothelial cells, smooth muscle cells and cardiomyocytes. In this review, we summarize the unique and redundant functions of Ena/VASP proteins in cardiovascular cells and discuss the underlying molecular mechanisms.
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spelling pubmed-103404262023-07-14 Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond Benz, Peter M. Frömel, Timo Laban, Hebatullah Zink, Joana Ulrich, Lea Groneberg, Dieter Boon, Reinier A. Poley, Philip Renne, Thomas de Wit, Cor Fleming, Ingrid Cells Review Actin binding proteins are of crucial importance for the spatiotemporal regulation of actin cytoskeletal dynamics, thereby mediating a tremendous range of cellular processes. Since their initial discovery more than 30 years ago, the enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) family has evolved as one of the most fascinating and versatile family of actin regulating proteins. The proteins directly enhance actin filament assembly, but they also organize higher order actin networks and link kinase signaling pathways to actin filament assembly. Thereby, Ena/VASP proteins regulate dynamic cellular processes ranging from membrane protrusions and trafficking, and cell-cell and cell-matrix adhesions, to the generation of mechanical tension and contractile force. Important insights have been gained into the physiological functions of Ena/VASP proteins in platelets, leukocytes, endothelial cells, smooth muscle cells and cardiomyocytes. In this review, we summarize the unique and redundant functions of Ena/VASP proteins in cardiovascular cells and discuss the underlying molecular mechanisms. MDPI 2023-06-28 /pmc/articles/PMC10340426/ /pubmed/37443774 http://dx.doi.org/10.3390/cells12131740 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Benz, Peter M.
Frömel, Timo
Laban, Hebatullah
Zink, Joana
Ulrich, Lea
Groneberg, Dieter
Boon, Reinier A.
Poley, Philip
Renne, Thomas
de Wit, Cor
Fleming, Ingrid
Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond
title Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond
title_full Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond
title_fullStr Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond
title_full_unstemmed Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond
title_short Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond
title_sort cardiovascular functions of ena/vasp proteins: past, present and beyond
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340426/
https://www.ncbi.nlm.nih.gov/pubmed/37443774
http://dx.doi.org/10.3390/cells12131740
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