Cargando…
Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond
Actin binding proteins are of crucial importance for the spatiotemporal regulation of actin cytoskeletal dynamics, thereby mediating a tremendous range of cellular processes. Since their initial discovery more than 30 years ago, the enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) family has...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340426/ https://www.ncbi.nlm.nih.gov/pubmed/37443774 http://dx.doi.org/10.3390/cells12131740 |
_version_ | 1785072076964495360 |
---|---|
author | Benz, Peter M. Frömel, Timo Laban, Hebatullah Zink, Joana Ulrich, Lea Groneberg, Dieter Boon, Reinier A. Poley, Philip Renne, Thomas de Wit, Cor Fleming, Ingrid |
author_facet | Benz, Peter M. Frömel, Timo Laban, Hebatullah Zink, Joana Ulrich, Lea Groneberg, Dieter Boon, Reinier A. Poley, Philip Renne, Thomas de Wit, Cor Fleming, Ingrid |
author_sort | Benz, Peter M. |
collection | PubMed |
description | Actin binding proteins are of crucial importance for the spatiotemporal regulation of actin cytoskeletal dynamics, thereby mediating a tremendous range of cellular processes. Since their initial discovery more than 30 years ago, the enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) family has evolved as one of the most fascinating and versatile family of actin regulating proteins. The proteins directly enhance actin filament assembly, but they also organize higher order actin networks and link kinase signaling pathways to actin filament assembly. Thereby, Ena/VASP proteins regulate dynamic cellular processes ranging from membrane protrusions and trafficking, and cell-cell and cell-matrix adhesions, to the generation of mechanical tension and contractile force. Important insights have been gained into the physiological functions of Ena/VASP proteins in platelets, leukocytes, endothelial cells, smooth muscle cells and cardiomyocytes. In this review, we summarize the unique and redundant functions of Ena/VASP proteins in cardiovascular cells and discuss the underlying molecular mechanisms. |
format | Online Article Text |
id | pubmed-10340426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103404262023-07-14 Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond Benz, Peter M. Frömel, Timo Laban, Hebatullah Zink, Joana Ulrich, Lea Groneberg, Dieter Boon, Reinier A. Poley, Philip Renne, Thomas de Wit, Cor Fleming, Ingrid Cells Review Actin binding proteins are of crucial importance for the spatiotemporal regulation of actin cytoskeletal dynamics, thereby mediating a tremendous range of cellular processes. Since their initial discovery more than 30 years ago, the enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) family has evolved as one of the most fascinating and versatile family of actin regulating proteins. The proteins directly enhance actin filament assembly, but they also organize higher order actin networks and link kinase signaling pathways to actin filament assembly. Thereby, Ena/VASP proteins regulate dynamic cellular processes ranging from membrane protrusions and trafficking, and cell-cell and cell-matrix adhesions, to the generation of mechanical tension and contractile force. Important insights have been gained into the physiological functions of Ena/VASP proteins in platelets, leukocytes, endothelial cells, smooth muscle cells and cardiomyocytes. In this review, we summarize the unique and redundant functions of Ena/VASP proteins in cardiovascular cells and discuss the underlying molecular mechanisms. MDPI 2023-06-28 /pmc/articles/PMC10340426/ /pubmed/37443774 http://dx.doi.org/10.3390/cells12131740 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Benz, Peter M. Frömel, Timo Laban, Hebatullah Zink, Joana Ulrich, Lea Groneberg, Dieter Boon, Reinier A. Poley, Philip Renne, Thomas de Wit, Cor Fleming, Ingrid Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond |
title | Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond |
title_full | Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond |
title_fullStr | Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond |
title_full_unstemmed | Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond |
title_short | Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond |
title_sort | cardiovascular functions of ena/vasp proteins: past, present and beyond |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340426/ https://www.ncbi.nlm.nih.gov/pubmed/37443774 http://dx.doi.org/10.3390/cells12131740 |
work_keys_str_mv | AT benzpeterm cardiovascularfunctionsofenavaspproteinspastpresentandbeyond AT fromeltimo cardiovascularfunctionsofenavaspproteinspastpresentandbeyond AT labanhebatullah cardiovascularfunctionsofenavaspproteinspastpresentandbeyond AT zinkjoana cardiovascularfunctionsofenavaspproteinspastpresentandbeyond AT ulrichlea cardiovascularfunctionsofenavaspproteinspastpresentandbeyond AT gronebergdieter cardiovascularfunctionsofenavaspproteinspastpresentandbeyond AT boonreiniera cardiovascularfunctionsofenavaspproteinspastpresentandbeyond AT poleyphilip cardiovascularfunctionsofenavaspproteinspastpresentandbeyond AT rennethomas cardiovascularfunctionsofenavaspproteinspastpresentandbeyond AT dewitcor cardiovascularfunctionsofenavaspproteinspastpresentandbeyond AT flemingingrid cardiovascularfunctionsofenavaspproteinspastpresentandbeyond |