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Hemoglobin and Endotoxin Levels Predict Sarcopenia Occurrence in Patients with Alcoholic Cirrhosis
Alcohol is a major risk factor of liver cirrhosis (LC). This study aimed to elucidate a surrogate marker of sarcopenia in patients with LC of different etiology. Out of 775 patients with LC, 451 were assessed for handgrip strength and skeletal muscle mass (by computed tomography). They were then div...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340466/ https://www.ncbi.nlm.nih.gov/pubmed/37443613 http://dx.doi.org/10.3390/diagnostics13132218 |
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author | Shibamoto, Akihiko Namisaki, Tadashi Suzuki, Junya Kubo, Takahiro Iwai, Satoshi Tomooka, Fumimasa Takeda, Soichi Fujimoto, Yuki Inoue, Takashi Tanaka, Misako Koizumi, Aritoshi Yorioka, Nobuyuki Matsuda, Takuya Asada, Shohei Tsuji, Yuki Fujinaga, Yukihisa Nishimura, Norihisa Sato, Shinya Takaya, Hiroaki Kitagawa, Koh Kaji, Kosuke Kawaratani, Hideto Akahane, Takemi Mitoro, Akira Yoshiji, Hitoshi |
author_facet | Shibamoto, Akihiko Namisaki, Tadashi Suzuki, Junya Kubo, Takahiro Iwai, Satoshi Tomooka, Fumimasa Takeda, Soichi Fujimoto, Yuki Inoue, Takashi Tanaka, Misako Koizumi, Aritoshi Yorioka, Nobuyuki Matsuda, Takuya Asada, Shohei Tsuji, Yuki Fujinaga, Yukihisa Nishimura, Norihisa Sato, Shinya Takaya, Hiroaki Kitagawa, Koh Kaji, Kosuke Kawaratani, Hideto Akahane, Takemi Mitoro, Akira Yoshiji, Hitoshi |
author_sort | Shibamoto, Akihiko |
collection | PubMed |
description | Alcohol is a major risk factor of liver cirrhosis (LC). This study aimed to elucidate a surrogate marker of sarcopenia in patients with LC of different etiology. Out of 775 patients with LC, 451 were assessed for handgrip strength and skeletal muscle mass (by computed tomography). They were then divided into two groups: alcoholic cirrhosis (AC; n = 149) and nonalcoholic cirrhosis (NAC; n = 302). Endotoxin activity (EA) levels were measured with an EA assay. Group AC showed significantly higher platelet counts (p = 0.027) and lower blood urea nitrogen levels and fibrosis-4 index than group NAC (p = 0.0020 and p = 0.038, respectively). The risk factors of sarcopenia were age ≥ 65 years, female sex, CP-C LC, Hb levels < 12 g/dL, and EA level > 0.4 in all patients with LC; hemoglobin (Hb) levels < 12 g/dL and EA level > 0.4 in group AC; and age ≥ 65 years, CP-C LC, and Hb levels < 12 g/dL in group NAC. The prediction accuracy of Hb for sarcopenia in group AC, group NAC, and all patients was 83.6%, 75.9%, and 78.1% (sensitivity: 92.0%, 69.0%, and 80.2%; specificity: 66.4%, 71.0%, and 64.0%), respectively. Although not significant, the predictive performance was better when using the combination of Hb and EA measurements than when using Hb alone in group AC but was comparable in all patients. Hb levels can predict sarcopenia in patients with LC, but in those with AC, the combination of Hb and EA improves the prediction performance. |
format | Online Article Text |
id | pubmed-10340466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103404662023-07-14 Hemoglobin and Endotoxin Levels Predict Sarcopenia Occurrence in Patients with Alcoholic Cirrhosis Shibamoto, Akihiko Namisaki, Tadashi Suzuki, Junya Kubo, Takahiro Iwai, Satoshi Tomooka, Fumimasa Takeda, Soichi Fujimoto, Yuki Inoue, Takashi Tanaka, Misako Koizumi, Aritoshi Yorioka, Nobuyuki Matsuda, Takuya Asada, Shohei Tsuji, Yuki Fujinaga, Yukihisa Nishimura, Norihisa Sato, Shinya Takaya, Hiroaki Kitagawa, Koh Kaji, Kosuke Kawaratani, Hideto Akahane, Takemi Mitoro, Akira Yoshiji, Hitoshi Diagnostics (Basel) Article Alcohol is a major risk factor of liver cirrhosis (LC). This study aimed to elucidate a surrogate marker of sarcopenia in patients with LC of different etiology. Out of 775 patients with LC, 451 were assessed for handgrip strength and skeletal muscle mass (by computed tomography). They were then divided into two groups: alcoholic cirrhosis (AC; n = 149) and nonalcoholic cirrhosis (NAC; n = 302). Endotoxin activity (EA) levels were measured with an EA assay. Group AC showed significantly higher platelet counts (p = 0.027) and lower blood urea nitrogen levels and fibrosis-4 index than group NAC (p = 0.0020 and p = 0.038, respectively). The risk factors of sarcopenia were age ≥ 65 years, female sex, CP-C LC, Hb levels < 12 g/dL, and EA level > 0.4 in all patients with LC; hemoglobin (Hb) levels < 12 g/dL and EA level > 0.4 in group AC; and age ≥ 65 years, CP-C LC, and Hb levels < 12 g/dL in group NAC. The prediction accuracy of Hb for sarcopenia in group AC, group NAC, and all patients was 83.6%, 75.9%, and 78.1% (sensitivity: 92.0%, 69.0%, and 80.2%; specificity: 66.4%, 71.0%, and 64.0%), respectively. Although not significant, the predictive performance was better when using the combination of Hb and EA measurements than when using Hb alone in group AC but was comparable in all patients. Hb levels can predict sarcopenia in patients with LC, but in those with AC, the combination of Hb and EA improves the prediction performance. MDPI 2023-06-29 /pmc/articles/PMC10340466/ /pubmed/37443613 http://dx.doi.org/10.3390/diagnostics13132218 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shibamoto, Akihiko Namisaki, Tadashi Suzuki, Junya Kubo, Takahiro Iwai, Satoshi Tomooka, Fumimasa Takeda, Soichi Fujimoto, Yuki Inoue, Takashi Tanaka, Misako Koizumi, Aritoshi Yorioka, Nobuyuki Matsuda, Takuya Asada, Shohei Tsuji, Yuki Fujinaga, Yukihisa Nishimura, Norihisa Sato, Shinya Takaya, Hiroaki Kitagawa, Koh Kaji, Kosuke Kawaratani, Hideto Akahane, Takemi Mitoro, Akira Yoshiji, Hitoshi Hemoglobin and Endotoxin Levels Predict Sarcopenia Occurrence in Patients with Alcoholic Cirrhosis |
title | Hemoglobin and Endotoxin Levels Predict Sarcopenia Occurrence in Patients with Alcoholic Cirrhosis |
title_full | Hemoglobin and Endotoxin Levels Predict Sarcopenia Occurrence in Patients with Alcoholic Cirrhosis |
title_fullStr | Hemoglobin and Endotoxin Levels Predict Sarcopenia Occurrence in Patients with Alcoholic Cirrhosis |
title_full_unstemmed | Hemoglobin and Endotoxin Levels Predict Sarcopenia Occurrence in Patients with Alcoholic Cirrhosis |
title_short | Hemoglobin and Endotoxin Levels Predict Sarcopenia Occurrence in Patients with Alcoholic Cirrhosis |
title_sort | hemoglobin and endotoxin levels predict sarcopenia occurrence in patients with alcoholic cirrhosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340466/ https://www.ncbi.nlm.nih.gov/pubmed/37443613 http://dx.doi.org/10.3390/diagnostics13132218 |
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