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Hemoglobin and Endotoxin Levels Predict Sarcopenia Occurrence in Patients with Alcoholic Cirrhosis

Alcohol is a major risk factor of liver cirrhosis (LC). This study aimed to elucidate a surrogate marker of sarcopenia in patients with LC of different etiology. Out of 775 patients with LC, 451 were assessed for handgrip strength and skeletal muscle mass (by computed tomography). They were then div...

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Autores principales: Shibamoto, Akihiko, Namisaki, Tadashi, Suzuki, Junya, Kubo, Takahiro, Iwai, Satoshi, Tomooka, Fumimasa, Takeda, Soichi, Fujimoto, Yuki, Inoue, Takashi, Tanaka, Misako, Koizumi, Aritoshi, Yorioka, Nobuyuki, Matsuda, Takuya, Asada, Shohei, Tsuji, Yuki, Fujinaga, Yukihisa, Nishimura, Norihisa, Sato, Shinya, Takaya, Hiroaki, Kitagawa, Koh, Kaji, Kosuke, Kawaratani, Hideto, Akahane, Takemi, Mitoro, Akira, Yoshiji, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340466/
https://www.ncbi.nlm.nih.gov/pubmed/37443613
http://dx.doi.org/10.3390/diagnostics13132218
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author Shibamoto, Akihiko
Namisaki, Tadashi
Suzuki, Junya
Kubo, Takahiro
Iwai, Satoshi
Tomooka, Fumimasa
Takeda, Soichi
Fujimoto, Yuki
Inoue, Takashi
Tanaka, Misako
Koizumi, Aritoshi
Yorioka, Nobuyuki
Matsuda, Takuya
Asada, Shohei
Tsuji, Yuki
Fujinaga, Yukihisa
Nishimura, Norihisa
Sato, Shinya
Takaya, Hiroaki
Kitagawa, Koh
Kaji, Kosuke
Kawaratani, Hideto
Akahane, Takemi
Mitoro, Akira
Yoshiji, Hitoshi
author_facet Shibamoto, Akihiko
Namisaki, Tadashi
Suzuki, Junya
Kubo, Takahiro
Iwai, Satoshi
Tomooka, Fumimasa
Takeda, Soichi
Fujimoto, Yuki
Inoue, Takashi
Tanaka, Misako
Koizumi, Aritoshi
Yorioka, Nobuyuki
Matsuda, Takuya
Asada, Shohei
Tsuji, Yuki
Fujinaga, Yukihisa
Nishimura, Norihisa
Sato, Shinya
Takaya, Hiroaki
Kitagawa, Koh
Kaji, Kosuke
Kawaratani, Hideto
Akahane, Takemi
Mitoro, Akira
Yoshiji, Hitoshi
author_sort Shibamoto, Akihiko
collection PubMed
description Alcohol is a major risk factor of liver cirrhosis (LC). This study aimed to elucidate a surrogate marker of sarcopenia in patients with LC of different etiology. Out of 775 patients with LC, 451 were assessed for handgrip strength and skeletal muscle mass (by computed tomography). They were then divided into two groups: alcoholic cirrhosis (AC; n = 149) and nonalcoholic cirrhosis (NAC; n = 302). Endotoxin activity (EA) levels were measured with an EA assay. Group AC showed significantly higher platelet counts (p = 0.027) and lower blood urea nitrogen levels and fibrosis-4 index than group NAC (p = 0.0020 and p = 0.038, respectively). The risk factors of sarcopenia were age ≥ 65 years, female sex, CP-C LC, Hb levels < 12 g/dL, and EA level > 0.4 in all patients with LC; hemoglobin (Hb) levels < 12 g/dL and EA level > 0.4 in group AC; and age ≥ 65 years, CP-C LC, and Hb levels < 12 g/dL in group NAC. The prediction accuracy of Hb for sarcopenia in group AC, group NAC, and all patients was 83.6%, 75.9%, and 78.1% (sensitivity: 92.0%, 69.0%, and 80.2%; specificity: 66.4%, 71.0%, and 64.0%), respectively. Although not significant, the predictive performance was better when using the combination of Hb and EA measurements than when using Hb alone in group AC but was comparable in all patients. Hb levels can predict sarcopenia in patients with LC, but in those with AC, the combination of Hb and EA improves the prediction performance.
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spelling pubmed-103404662023-07-14 Hemoglobin and Endotoxin Levels Predict Sarcopenia Occurrence in Patients with Alcoholic Cirrhosis Shibamoto, Akihiko Namisaki, Tadashi Suzuki, Junya Kubo, Takahiro Iwai, Satoshi Tomooka, Fumimasa Takeda, Soichi Fujimoto, Yuki Inoue, Takashi Tanaka, Misako Koizumi, Aritoshi Yorioka, Nobuyuki Matsuda, Takuya Asada, Shohei Tsuji, Yuki Fujinaga, Yukihisa Nishimura, Norihisa Sato, Shinya Takaya, Hiroaki Kitagawa, Koh Kaji, Kosuke Kawaratani, Hideto Akahane, Takemi Mitoro, Akira Yoshiji, Hitoshi Diagnostics (Basel) Article Alcohol is a major risk factor of liver cirrhosis (LC). This study aimed to elucidate a surrogate marker of sarcopenia in patients with LC of different etiology. Out of 775 patients with LC, 451 were assessed for handgrip strength and skeletal muscle mass (by computed tomography). They were then divided into two groups: alcoholic cirrhosis (AC; n = 149) and nonalcoholic cirrhosis (NAC; n = 302). Endotoxin activity (EA) levels were measured with an EA assay. Group AC showed significantly higher platelet counts (p = 0.027) and lower blood urea nitrogen levels and fibrosis-4 index than group NAC (p = 0.0020 and p = 0.038, respectively). The risk factors of sarcopenia were age ≥ 65 years, female sex, CP-C LC, Hb levels < 12 g/dL, and EA level > 0.4 in all patients with LC; hemoglobin (Hb) levels < 12 g/dL and EA level > 0.4 in group AC; and age ≥ 65 years, CP-C LC, and Hb levels < 12 g/dL in group NAC. The prediction accuracy of Hb for sarcopenia in group AC, group NAC, and all patients was 83.6%, 75.9%, and 78.1% (sensitivity: 92.0%, 69.0%, and 80.2%; specificity: 66.4%, 71.0%, and 64.0%), respectively. Although not significant, the predictive performance was better when using the combination of Hb and EA measurements than when using Hb alone in group AC but was comparable in all patients. Hb levels can predict sarcopenia in patients with LC, but in those with AC, the combination of Hb and EA improves the prediction performance. MDPI 2023-06-29 /pmc/articles/PMC10340466/ /pubmed/37443613 http://dx.doi.org/10.3390/diagnostics13132218 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shibamoto, Akihiko
Namisaki, Tadashi
Suzuki, Junya
Kubo, Takahiro
Iwai, Satoshi
Tomooka, Fumimasa
Takeda, Soichi
Fujimoto, Yuki
Inoue, Takashi
Tanaka, Misako
Koizumi, Aritoshi
Yorioka, Nobuyuki
Matsuda, Takuya
Asada, Shohei
Tsuji, Yuki
Fujinaga, Yukihisa
Nishimura, Norihisa
Sato, Shinya
Takaya, Hiroaki
Kitagawa, Koh
Kaji, Kosuke
Kawaratani, Hideto
Akahane, Takemi
Mitoro, Akira
Yoshiji, Hitoshi
Hemoglobin and Endotoxin Levels Predict Sarcopenia Occurrence in Patients with Alcoholic Cirrhosis
title Hemoglobin and Endotoxin Levels Predict Sarcopenia Occurrence in Patients with Alcoholic Cirrhosis
title_full Hemoglobin and Endotoxin Levels Predict Sarcopenia Occurrence in Patients with Alcoholic Cirrhosis
title_fullStr Hemoglobin and Endotoxin Levels Predict Sarcopenia Occurrence in Patients with Alcoholic Cirrhosis
title_full_unstemmed Hemoglobin and Endotoxin Levels Predict Sarcopenia Occurrence in Patients with Alcoholic Cirrhosis
title_short Hemoglobin and Endotoxin Levels Predict Sarcopenia Occurrence in Patients with Alcoholic Cirrhosis
title_sort hemoglobin and endotoxin levels predict sarcopenia occurrence in patients with alcoholic cirrhosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340466/
https://www.ncbi.nlm.nih.gov/pubmed/37443613
http://dx.doi.org/10.3390/diagnostics13132218
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