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Super-High Magnification Dermoscopy in 190 Clinically Atypical Pigmented Lesions

Super-high (×400) magnification dermoscopy (D400) is a new non-invasive imaging technique that has been shown to add information for the differential diagnosis of melanocytic lesions in a pilot study. Our study aimed to confirm if D400 can add details for the discrimination of clinically atypical ne...

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Autores principales: Cinotti, Elisa, Cioppa, Vittoria, Tognetti, Linda, Perrot, Jean Luc, Rossi, Renato, Gnone, Matteo, Cartocci, Alessandra, Rubegni, Pietro, Cortonesi, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340569/
https://www.ncbi.nlm.nih.gov/pubmed/37443632
http://dx.doi.org/10.3390/diagnostics13132238
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author Cinotti, Elisa
Cioppa, Vittoria
Tognetti, Linda
Perrot, Jean Luc
Rossi, Renato
Gnone, Matteo
Cartocci, Alessandra
Rubegni, Pietro
Cortonesi, Giulio
author_facet Cinotti, Elisa
Cioppa, Vittoria
Tognetti, Linda
Perrot, Jean Luc
Rossi, Renato
Gnone, Matteo
Cartocci, Alessandra
Rubegni, Pietro
Cortonesi, Giulio
author_sort Cinotti, Elisa
collection PubMed
description Super-high (×400) magnification dermoscopy (D400) is a new non-invasive imaging technique that has been shown to add information for the differential diagnosis of melanocytic lesions in a pilot study. Our study aimed to confirm if D400 can add details for the discrimination of clinically atypical nevus and melanoma. This is a retrospective observational, multicentric study enrolling patients who received ×20 (D20) and ×400 (D400) magnification dermoscopic examinations of pigmented skin lesions. Dermoscopic images were retrospectively evaluated by three observers for the presence/absence of nine D20 and twenty D400 dermoscopic features defined in the previous pilot study. Univariate and multivariate analyses were carried out to find predictors of benign and malignant behaviors. At D20, an atypical pigment network, blue-whitish veil, atypical vascular pattern, regression, and homogenous pattern were more frequent in melanoma than in nevi (p < 0.001). At D400, melanoma showed more frequently than benign lesions, melanocytes with an irregular arrangement and irregular in shape and size (p < 0.001). A network with edged papillae was more frequent in benign lesions than melanomas (p < 0.001). Our study confirms that D400 can identify melanocytes with an irregular arrangement, and irregularities in shape and size in melanomas, adding information to the conventional D20 examination.
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spelling pubmed-103405692023-07-14 Super-High Magnification Dermoscopy in 190 Clinically Atypical Pigmented Lesions Cinotti, Elisa Cioppa, Vittoria Tognetti, Linda Perrot, Jean Luc Rossi, Renato Gnone, Matteo Cartocci, Alessandra Rubegni, Pietro Cortonesi, Giulio Diagnostics (Basel) Article Super-high (×400) magnification dermoscopy (D400) is a new non-invasive imaging technique that has been shown to add information for the differential diagnosis of melanocytic lesions in a pilot study. Our study aimed to confirm if D400 can add details for the discrimination of clinically atypical nevus and melanoma. This is a retrospective observational, multicentric study enrolling patients who received ×20 (D20) and ×400 (D400) magnification dermoscopic examinations of pigmented skin lesions. Dermoscopic images were retrospectively evaluated by three observers for the presence/absence of nine D20 and twenty D400 dermoscopic features defined in the previous pilot study. Univariate and multivariate analyses were carried out to find predictors of benign and malignant behaviors. At D20, an atypical pigment network, blue-whitish veil, atypical vascular pattern, regression, and homogenous pattern were more frequent in melanoma than in nevi (p < 0.001). At D400, melanoma showed more frequently than benign lesions, melanocytes with an irregular arrangement and irregular in shape and size (p < 0.001). A network with edged papillae was more frequent in benign lesions than melanomas (p < 0.001). Our study confirms that D400 can identify melanocytes with an irregular arrangement, and irregularities in shape and size in melanomas, adding information to the conventional D20 examination. MDPI 2023-06-30 /pmc/articles/PMC10340569/ /pubmed/37443632 http://dx.doi.org/10.3390/diagnostics13132238 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cinotti, Elisa
Cioppa, Vittoria
Tognetti, Linda
Perrot, Jean Luc
Rossi, Renato
Gnone, Matteo
Cartocci, Alessandra
Rubegni, Pietro
Cortonesi, Giulio
Super-High Magnification Dermoscopy in 190 Clinically Atypical Pigmented Lesions
title Super-High Magnification Dermoscopy in 190 Clinically Atypical Pigmented Lesions
title_full Super-High Magnification Dermoscopy in 190 Clinically Atypical Pigmented Lesions
title_fullStr Super-High Magnification Dermoscopy in 190 Clinically Atypical Pigmented Lesions
title_full_unstemmed Super-High Magnification Dermoscopy in 190 Clinically Atypical Pigmented Lesions
title_short Super-High Magnification Dermoscopy in 190 Clinically Atypical Pigmented Lesions
title_sort super-high magnification dermoscopy in 190 clinically atypical pigmented lesions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340569/
https://www.ncbi.nlm.nih.gov/pubmed/37443632
http://dx.doi.org/10.3390/diagnostics13132238
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