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Maternal Exposure to Potentially Toxic Metals and Birth Weight: Preliminary Results from the DSAN-12M Birth Cohort in the Recôncavo Baiano, Brazil

Prenatal exposure to potentially toxic metals (PTM) may impair fetal growth (FG). We investigated the relationship between maternal exposure to lead (Pb), cadmium (Cd) and manganese (Mn) and birth weight (BW) of 74 newborns. Blood was collected during the second trimester of pregnancy to determine P...

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Autores principales: Bah, Homègnon A. Ferréol, dos Santos, Nathália R., Gomes Junior, Erival A., Costa, Daisy O., Martinez, Victor O., Pires, Elis Macêdo, Santana, João V. Araújo, Cerqueira, Filipe da Silva, Menezes-Filho, José A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340643/
https://www.ncbi.nlm.nih.gov/pubmed/37444059
http://dx.doi.org/10.3390/ijerph20136211
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author Bah, Homègnon A. Ferréol
dos Santos, Nathália R.
Gomes Junior, Erival A.
Costa, Daisy O.
Martinez, Victor O.
Pires, Elis Macêdo
Santana, João V. Araújo
Cerqueira, Filipe da Silva
Menezes-Filho, José A.
author_facet Bah, Homègnon A. Ferréol
dos Santos, Nathália R.
Gomes Junior, Erival A.
Costa, Daisy O.
Martinez, Victor O.
Pires, Elis Macêdo
Santana, João V. Araújo
Cerqueira, Filipe da Silva
Menezes-Filho, José A.
author_sort Bah, Homègnon A. Ferréol
collection PubMed
description Prenatal exposure to potentially toxic metals (PTM) may impair fetal growth (FG). We investigated the relationship between maternal exposure to lead (Pb), cadmium (Cd) and manganese (Mn) and birth weight (BW) of 74 newborns. Blood was collected during the second trimester of pregnancy to determine Pb (PbB) and Cd (CdB), while hair (MnH) and toenails (MnTn) were used for Mn. Samples were analyzed by graphite furnace atomic absorption spectrophotometry (GFAAS). Sociodemographic and BW data were collected from questionnaires and maternity records, respectively. The medians (P25th–P75th) of PbB, CdB, MnH, and MnTn were, respectively, 0.9 (0.5–1.8) µg/dL; 0.54 (0.1–0.8) µg/L; 0.18 (0.1–0.4) µg/g; and 0.65 (0.37–1.22) µg/g. The means (standard deviation) of birth weight according to sex were 3067 (426.3) and 3442 (431) grams, respectively, for girls and boys. MnTn presented an inverse correlation with the BW/gestational age ratio for girls (rho = −0.478; p = 0.018), suggesting the effect of sex modification. Although BW correlation with CdB was not statistically significant, hierarchical linear regression (beta = −2.08; 95% CI–4.58 to 0.41) suggested a fetotoxic effect. These results confirmed the threat PTMs may represent and the need for more extensive research to elucidate their role in inadequate FG in developing countries.
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spelling pubmed-103406432023-07-14 Maternal Exposure to Potentially Toxic Metals and Birth Weight: Preliminary Results from the DSAN-12M Birth Cohort in the Recôncavo Baiano, Brazil Bah, Homègnon A. Ferréol dos Santos, Nathália R. Gomes Junior, Erival A. Costa, Daisy O. Martinez, Victor O. Pires, Elis Macêdo Santana, João V. Araújo Cerqueira, Filipe da Silva Menezes-Filho, José A. Int J Environ Res Public Health Article Prenatal exposure to potentially toxic metals (PTM) may impair fetal growth (FG). We investigated the relationship between maternal exposure to lead (Pb), cadmium (Cd) and manganese (Mn) and birth weight (BW) of 74 newborns. Blood was collected during the second trimester of pregnancy to determine Pb (PbB) and Cd (CdB), while hair (MnH) and toenails (MnTn) were used for Mn. Samples were analyzed by graphite furnace atomic absorption spectrophotometry (GFAAS). Sociodemographic and BW data were collected from questionnaires and maternity records, respectively. The medians (P25th–P75th) of PbB, CdB, MnH, and MnTn were, respectively, 0.9 (0.5–1.8) µg/dL; 0.54 (0.1–0.8) µg/L; 0.18 (0.1–0.4) µg/g; and 0.65 (0.37–1.22) µg/g. The means (standard deviation) of birth weight according to sex were 3067 (426.3) and 3442 (431) grams, respectively, for girls and boys. MnTn presented an inverse correlation with the BW/gestational age ratio for girls (rho = −0.478; p = 0.018), suggesting the effect of sex modification. Although BW correlation with CdB was not statistically significant, hierarchical linear regression (beta = −2.08; 95% CI–4.58 to 0.41) suggested a fetotoxic effect. These results confirmed the threat PTMs may represent and the need for more extensive research to elucidate their role in inadequate FG in developing countries. MDPI 2023-06-23 /pmc/articles/PMC10340643/ /pubmed/37444059 http://dx.doi.org/10.3390/ijerph20136211 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bah, Homègnon A. Ferréol
dos Santos, Nathália R.
Gomes Junior, Erival A.
Costa, Daisy O.
Martinez, Victor O.
Pires, Elis Macêdo
Santana, João V. Araújo
Cerqueira, Filipe da Silva
Menezes-Filho, José A.
Maternal Exposure to Potentially Toxic Metals and Birth Weight: Preliminary Results from the DSAN-12M Birth Cohort in the Recôncavo Baiano, Brazil
title Maternal Exposure to Potentially Toxic Metals and Birth Weight: Preliminary Results from the DSAN-12M Birth Cohort in the Recôncavo Baiano, Brazil
title_full Maternal Exposure to Potentially Toxic Metals and Birth Weight: Preliminary Results from the DSAN-12M Birth Cohort in the Recôncavo Baiano, Brazil
title_fullStr Maternal Exposure to Potentially Toxic Metals and Birth Weight: Preliminary Results from the DSAN-12M Birth Cohort in the Recôncavo Baiano, Brazil
title_full_unstemmed Maternal Exposure to Potentially Toxic Metals and Birth Weight: Preliminary Results from the DSAN-12M Birth Cohort in the Recôncavo Baiano, Brazil
title_short Maternal Exposure to Potentially Toxic Metals and Birth Weight: Preliminary Results from the DSAN-12M Birth Cohort in the Recôncavo Baiano, Brazil
title_sort maternal exposure to potentially toxic metals and birth weight: preliminary results from the dsan-12m birth cohort in the recôncavo baiano, brazil
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340643/
https://www.ncbi.nlm.nih.gov/pubmed/37444059
http://dx.doi.org/10.3390/ijerph20136211
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