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Feasibility of Diffusion Tensor Imaging for Decreasing Biopsy Rates in Breast Imaging: Interim Analysis of a Prospective Study

Because of the limited specificity of diagnostic imaging, many breast lesions referred for biopsy turn out to be benign. The objective of this study was to evaluate whether diffusion tensor MRI (DTI) parametric maps can be used to safely avoid biopsy of breast lesions. Individuals referred for breas...

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Autores principales: Ecanow, Jacob S., Ecanow, David B., Hack, Bradley, Leloudas, Nondas, Prasad, Pottumarthi V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340646/
https://www.ncbi.nlm.nih.gov/pubmed/37443620
http://dx.doi.org/10.3390/diagnostics13132226
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author Ecanow, Jacob S.
Ecanow, David B.
Hack, Bradley
Leloudas, Nondas
Prasad, Pottumarthi V.
author_facet Ecanow, Jacob S.
Ecanow, David B.
Hack, Bradley
Leloudas, Nondas
Prasad, Pottumarthi V.
author_sort Ecanow, Jacob S.
collection PubMed
description Because of the limited specificity of diagnostic imaging, many breast lesions referred for biopsy turn out to be benign. The objective of this study was to evaluate whether diffusion tensor MRI (DTI) parametric maps can be used to safely avoid biopsy of breast lesions. Individuals referred for breast biopsy based on mammogram (MG), ultrasound (US), and/or contrast enhanced (CE)-MRI were recruited. Scans consisting of T2-weighted and DTI sequences were performed. Multiple DTI-derived parametric color maps were evaluated semi-quantitatively to characterize lesions as “definitely benign,” “not definitely benign,” or “suspicious.” All patients subsequently underwent biopsy. In this moderately-sized prospective study, 21 out of 47 pathologically proven benign lesions were characterized by both readers as “definitely benign,” which would have precluded the need for biopsy. Biopsy was recommended for 11 out of 13 cancers that were characterized as “suspicious.” In the remaining two cancers and 26 of 47 benign lesions, the scans were characterized as “not definitely benign” and hence required biopsy. The main causes for “not definitely benign” scans were small lesion sizes and noise. The results suggest that in appropriately selected patients, DTI may be used to safely reduce the number of unnecessary breast biopsies.
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spelling pubmed-103406462023-07-14 Feasibility of Diffusion Tensor Imaging for Decreasing Biopsy Rates in Breast Imaging: Interim Analysis of a Prospective Study Ecanow, Jacob S. Ecanow, David B. Hack, Bradley Leloudas, Nondas Prasad, Pottumarthi V. Diagnostics (Basel) Article Because of the limited specificity of diagnostic imaging, many breast lesions referred for biopsy turn out to be benign. The objective of this study was to evaluate whether diffusion tensor MRI (DTI) parametric maps can be used to safely avoid biopsy of breast lesions. Individuals referred for breast biopsy based on mammogram (MG), ultrasound (US), and/or contrast enhanced (CE)-MRI were recruited. Scans consisting of T2-weighted and DTI sequences were performed. Multiple DTI-derived parametric color maps were evaluated semi-quantitatively to characterize lesions as “definitely benign,” “not definitely benign,” or “suspicious.” All patients subsequently underwent biopsy. In this moderately-sized prospective study, 21 out of 47 pathologically proven benign lesions were characterized by both readers as “definitely benign,” which would have precluded the need for biopsy. Biopsy was recommended for 11 out of 13 cancers that were characterized as “suspicious.” In the remaining two cancers and 26 of 47 benign lesions, the scans were characterized as “not definitely benign” and hence required biopsy. The main causes for “not definitely benign” scans were small lesion sizes and noise. The results suggest that in appropriately selected patients, DTI may be used to safely reduce the number of unnecessary breast biopsies. MDPI 2023-06-30 /pmc/articles/PMC10340646/ /pubmed/37443620 http://dx.doi.org/10.3390/diagnostics13132226 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ecanow, Jacob S.
Ecanow, David B.
Hack, Bradley
Leloudas, Nondas
Prasad, Pottumarthi V.
Feasibility of Diffusion Tensor Imaging for Decreasing Biopsy Rates in Breast Imaging: Interim Analysis of a Prospective Study
title Feasibility of Diffusion Tensor Imaging for Decreasing Biopsy Rates in Breast Imaging: Interim Analysis of a Prospective Study
title_full Feasibility of Diffusion Tensor Imaging for Decreasing Biopsy Rates in Breast Imaging: Interim Analysis of a Prospective Study
title_fullStr Feasibility of Diffusion Tensor Imaging for Decreasing Biopsy Rates in Breast Imaging: Interim Analysis of a Prospective Study
title_full_unstemmed Feasibility of Diffusion Tensor Imaging for Decreasing Biopsy Rates in Breast Imaging: Interim Analysis of a Prospective Study
title_short Feasibility of Diffusion Tensor Imaging for Decreasing Biopsy Rates in Breast Imaging: Interim Analysis of a Prospective Study
title_sort feasibility of diffusion tensor imaging for decreasing biopsy rates in breast imaging: interim analysis of a prospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340646/
https://www.ncbi.nlm.nih.gov/pubmed/37443620
http://dx.doi.org/10.3390/diagnostics13132226
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