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Endovascular Treatment of Cerebral Vein Thrombosis: Safety and Effectiveness in the Thrombectomy Era

Cerebral venous thrombosis (CVT) is a rare cause of stroke that tends to affect young people. Endovascular treatment (EVT) has not yet shown to be beneficial in CVT and is therefore actually only indicated as rescue therapy in severe and refractory cases for medical treatment. Clinical, neuroimaging...

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Autores principales: Piano, Mariangela, Romi, Andrea, Cervo, Amedeo, Gatti, Antonella, Macera, Antonio, Pero, Guglielmo, Motto, Cristina, Agostoni, Elio Clemente, Lozupone, Emilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340702/
https://www.ncbi.nlm.nih.gov/pubmed/37443641
http://dx.doi.org/10.3390/diagnostics13132248
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author Piano, Mariangela
Romi, Andrea
Cervo, Amedeo
Gatti, Antonella
Macera, Antonio
Pero, Guglielmo
Motto, Cristina
Agostoni, Elio Clemente
Lozupone, Emilio
author_facet Piano, Mariangela
Romi, Andrea
Cervo, Amedeo
Gatti, Antonella
Macera, Antonio
Pero, Guglielmo
Motto, Cristina
Agostoni, Elio Clemente
Lozupone, Emilio
author_sort Piano, Mariangela
collection PubMed
description Cerebral venous thrombosis (CVT) is a rare cause of stroke that tends to affect young people. Endovascular treatment (EVT) has not yet shown to be beneficial in CVT and is therefore actually only indicated as rescue therapy in severe and refractory cases for medical treatment. Clinical, neuroimaging, procedural and follow-up data were evaluated in order to define the safety and efficacy of EVT in the management of CVT between January 2016 and December 2022. Safety was assessed on the basis of recording adverse events. Functional outcomes (NIHSS, mRS) and neuroimaging were recorded at onset, at discharge and at a 6-month follow-up. Efficacy was assessed evaluating the recanalization rate at the end of the procedure. Twenty-one patients (17 female, 4 male, range 16–84 years) with CVT underwent EVT. Overall morbidity and mortality were both at 4.7%. Median NIHSS at the onset and at the discharge were, respectively, 10 and 2. Successful recanalization was achieved in 21/23 procedures (91.3%). Imaging follow-up (FUP) showed stable recanalization in all but one patient with successful recanalization. In 18/21 patients, a good clinical independence (mRS 0–2) was recorded at 6 months. Our study adds evidence on the safety and efficacy of endovascular techniques in the treatment of CVT.
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spelling pubmed-103407022023-07-14 Endovascular Treatment of Cerebral Vein Thrombosis: Safety and Effectiveness in the Thrombectomy Era Piano, Mariangela Romi, Andrea Cervo, Amedeo Gatti, Antonella Macera, Antonio Pero, Guglielmo Motto, Cristina Agostoni, Elio Clemente Lozupone, Emilio Diagnostics (Basel) Article Cerebral venous thrombosis (CVT) is a rare cause of stroke that tends to affect young people. Endovascular treatment (EVT) has not yet shown to be beneficial in CVT and is therefore actually only indicated as rescue therapy in severe and refractory cases for medical treatment. Clinical, neuroimaging, procedural and follow-up data were evaluated in order to define the safety and efficacy of EVT in the management of CVT between January 2016 and December 2022. Safety was assessed on the basis of recording adverse events. Functional outcomes (NIHSS, mRS) and neuroimaging were recorded at onset, at discharge and at a 6-month follow-up. Efficacy was assessed evaluating the recanalization rate at the end of the procedure. Twenty-one patients (17 female, 4 male, range 16–84 years) with CVT underwent EVT. Overall morbidity and mortality were both at 4.7%. Median NIHSS at the onset and at the discharge were, respectively, 10 and 2. Successful recanalization was achieved in 21/23 procedures (91.3%). Imaging follow-up (FUP) showed stable recanalization in all but one patient with successful recanalization. In 18/21 patients, a good clinical independence (mRS 0–2) was recorded at 6 months. Our study adds evidence on the safety and efficacy of endovascular techniques in the treatment of CVT. MDPI 2023-07-03 /pmc/articles/PMC10340702/ /pubmed/37443641 http://dx.doi.org/10.3390/diagnostics13132248 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Piano, Mariangela
Romi, Andrea
Cervo, Amedeo
Gatti, Antonella
Macera, Antonio
Pero, Guglielmo
Motto, Cristina
Agostoni, Elio Clemente
Lozupone, Emilio
Endovascular Treatment of Cerebral Vein Thrombosis: Safety and Effectiveness in the Thrombectomy Era
title Endovascular Treatment of Cerebral Vein Thrombosis: Safety and Effectiveness in the Thrombectomy Era
title_full Endovascular Treatment of Cerebral Vein Thrombosis: Safety and Effectiveness in the Thrombectomy Era
title_fullStr Endovascular Treatment of Cerebral Vein Thrombosis: Safety and Effectiveness in the Thrombectomy Era
title_full_unstemmed Endovascular Treatment of Cerebral Vein Thrombosis: Safety and Effectiveness in the Thrombectomy Era
title_short Endovascular Treatment of Cerebral Vein Thrombosis: Safety and Effectiveness in the Thrombectomy Era
title_sort endovascular treatment of cerebral vein thrombosis: safety and effectiveness in the thrombectomy era
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340702/
https://www.ncbi.nlm.nih.gov/pubmed/37443641
http://dx.doi.org/10.3390/diagnostics13132248
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