TLR4 Overexpression Aggravates Bacterial Lipopolysaccharide-Induced Apoptosis via Excessive Autophagy and NF-κB/MAPK Signaling in Transgenic Mammal Models

Gram-negative bacterial infections pose a significant threat to public health. Toll-like receptor 4 (TLR4) recognizes bacterial lipopolysaccharide (LPS) and induces innate immune responses, autophagy, and cell death, which have major impacts on the body’s physiological homeostasis. However, the role...

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Detalles Bibliográficos
Autores principales: Wang, Sutian, Zhang, Kunli, Song, Xuting, Huang, Qiuyan, Lin, Sen, Deng, Shoulong, Qi, Meiyu, Yang, Yecheng, Lu, Qi, Zhao, Duowei, Meng, Fanming, Li, Jianhao, Lian, Zhengxing, Luo, Chenglong, Yao, Yuchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340758/
https://www.ncbi.nlm.nih.gov/pubmed/37443803
http://dx.doi.org/10.3390/cells12131769

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