Development of the NOGGO GIS v1 Assay, a Comprehensive Hybrid-Capture-Based NGS Assay for Therapeutic Stratification of Homologous Repair Deficiency Driven Tumors and Clinical Validation

SIMPLE SUMMARY: Genomic instability (GI) caused by homologous repair deficiency (HRD) is a novel highly clinically relevant biomarker that cannot only identify patients suffering from high-grade serous ovarian cancer that may benefit from poly-ADP ribose polymerase (PARP) inhibitors but also helps i...

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Detalles Bibliográficos
Autores principales: Willing, Eva-Maria, Vollbrecht, Claudia, Vössing, Christine, Weist, Peggy, Schallenberg, Simon, Herbst, Johanna M., Schatz, Stefanie, Jóri, Balázs, Bataillon, Guillaume, Harter, Philipp, Salutari, Vanda, Martin, Antonio Gonzáles, Vergote, Ignace, Colombo, Nicoletta, Roeper, Julia, Berg, Tobias, Berger, Regina, Kah, Bettina, Noettrup, Trine Jakobi, Falk, Markus, Arndt, Kathrin, Polten, Andreas, Ray-Coquard, Isabelle, Selzam, Franziska, Pirngruber, Judith, Schmidt, Stefanie, Hummel, Michael, Tiemann, Markus, Horst, David, Sehouli, Jalid, Pujade-Lauraine, Eric, Tiemann, Katharina, Braicu, Elena Ioana, Heukamp, Lukas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341077/
https://www.ncbi.nlm.nih.gov/pubmed/37444554
http://dx.doi.org/10.3390/cancers15133445

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