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Usefulness of Contrast-Enhanced Endoscopic Ultrasound (CH-EUS) to Guide the Treatment Choice in Superficial Rectal Lesions: A Case Series

Introduction: Large rectal lesions can conceal submucosal invasion and cancer nodules. Despite the increasing diffusion of high-definition endoscopes and the importance of an accurate morphological evaluation, a complete assessment in this setting can be challenging. Endoscopic ultrasound (EUS) play...

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Autores principales: Gibiino, Giulia, Sbrancia, Monica, Binda, Cecilia, Coluccio, Chiara, Fabbri, Stefano, Giuffrida, Paolo, Gallo, Graziana, Saragoni, Luca, Maselli, Roberta, Repici, Alessandro, Fabbri, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341096/
https://www.ncbi.nlm.nih.gov/pubmed/37443660
http://dx.doi.org/10.3390/diagnostics13132267
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author Gibiino, Giulia
Sbrancia, Monica
Binda, Cecilia
Coluccio, Chiara
Fabbri, Stefano
Giuffrida, Paolo
Gallo, Graziana
Saragoni, Luca
Maselli, Roberta
Repici, Alessandro
Fabbri, Carlo
author_facet Gibiino, Giulia
Sbrancia, Monica
Binda, Cecilia
Coluccio, Chiara
Fabbri, Stefano
Giuffrida, Paolo
Gallo, Graziana
Saragoni, Luca
Maselli, Roberta
Repici, Alessandro
Fabbri, Carlo
author_sort Gibiino, Giulia
collection PubMed
description Introduction: Large rectal lesions can conceal submucosal invasion and cancer nodules. Despite the increasing diffusion of high-definition endoscopes and the importance of an accurate morphological evaluation, a complete assessment in this setting can be challenging. Endoscopic ultrasound (EUS) plays an established role in the locoregional staging of rectal cancer, although this technique has a tendency toward the over-estimation of the loco-regional (T) staging. However, there are still few data on contrast-enhanced endoscopic ultrasound (CH-EUS), especially if this ancillary technique may increase the accuracy for predicting invasive nodules among large rectal lesions. Material and Methods: Consecutive large (≥20 mm) superficial rectal lesions with high-definition endoscopy, characterized by focal areas suggestive for invasive cancer/2B type according to JNET classification, were considered for additional standardized evaluation via CH-EUS with Sonovue ©. Results: From 2020 to 2023, we evaluated 12 consecutive superficial rectal lesions with sizes ranging from 20 to 180 mm. This evaluation provided additional elements to support the therapeutic decision made. Lesions were treated with surgical (3/12) or endoscopic treatment (9/12) according to their morphology and CH-EUS evaluation. Conclusion: Contrast-enhanced endoscopic ultrasound can provide an additional evaluation for large and difficult-to-classify rectal lesions. In our experience, CH-EUS staging corresponded to the final pathological stages in 9/12 (75%) lesions, improving the distinction between T1 and T2 lesions. Larger prospective studies and randomized trials should be conducted to support and standardize this approach.
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spelling pubmed-103410962023-07-14 Usefulness of Contrast-Enhanced Endoscopic Ultrasound (CH-EUS) to Guide the Treatment Choice in Superficial Rectal Lesions: A Case Series Gibiino, Giulia Sbrancia, Monica Binda, Cecilia Coluccio, Chiara Fabbri, Stefano Giuffrida, Paolo Gallo, Graziana Saragoni, Luca Maselli, Roberta Repici, Alessandro Fabbri, Carlo Diagnostics (Basel) Case Report Introduction: Large rectal lesions can conceal submucosal invasion and cancer nodules. Despite the increasing diffusion of high-definition endoscopes and the importance of an accurate morphological evaluation, a complete assessment in this setting can be challenging. Endoscopic ultrasound (EUS) plays an established role in the locoregional staging of rectal cancer, although this technique has a tendency toward the over-estimation of the loco-regional (T) staging. However, there are still few data on contrast-enhanced endoscopic ultrasound (CH-EUS), especially if this ancillary technique may increase the accuracy for predicting invasive nodules among large rectal lesions. Material and Methods: Consecutive large (≥20 mm) superficial rectal lesions with high-definition endoscopy, characterized by focal areas suggestive for invasive cancer/2B type according to JNET classification, were considered for additional standardized evaluation via CH-EUS with Sonovue ©. Results: From 2020 to 2023, we evaluated 12 consecutive superficial rectal lesions with sizes ranging from 20 to 180 mm. This evaluation provided additional elements to support the therapeutic decision made. Lesions were treated with surgical (3/12) or endoscopic treatment (9/12) according to their morphology and CH-EUS evaluation. Conclusion: Contrast-enhanced endoscopic ultrasound can provide an additional evaluation for large and difficult-to-classify rectal lesions. In our experience, CH-EUS staging corresponded to the final pathological stages in 9/12 (75%) lesions, improving the distinction between T1 and T2 lesions. Larger prospective studies and randomized trials should be conducted to support and standardize this approach. MDPI 2023-07-04 /pmc/articles/PMC10341096/ /pubmed/37443660 http://dx.doi.org/10.3390/diagnostics13132267 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Gibiino, Giulia
Sbrancia, Monica
Binda, Cecilia
Coluccio, Chiara
Fabbri, Stefano
Giuffrida, Paolo
Gallo, Graziana
Saragoni, Luca
Maselli, Roberta
Repici, Alessandro
Fabbri, Carlo
Usefulness of Contrast-Enhanced Endoscopic Ultrasound (CH-EUS) to Guide the Treatment Choice in Superficial Rectal Lesions: A Case Series
title Usefulness of Contrast-Enhanced Endoscopic Ultrasound (CH-EUS) to Guide the Treatment Choice in Superficial Rectal Lesions: A Case Series
title_full Usefulness of Contrast-Enhanced Endoscopic Ultrasound (CH-EUS) to Guide the Treatment Choice in Superficial Rectal Lesions: A Case Series
title_fullStr Usefulness of Contrast-Enhanced Endoscopic Ultrasound (CH-EUS) to Guide the Treatment Choice in Superficial Rectal Lesions: A Case Series
title_full_unstemmed Usefulness of Contrast-Enhanced Endoscopic Ultrasound (CH-EUS) to Guide the Treatment Choice in Superficial Rectal Lesions: A Case Series
title_short Usefulness of Contrast-Enhanced Endoscopic Ultrasound (CH-EUS) to Guide the Treatment Choice in Superficial Rectal Lesions: A Case Series
title_sort usefulness of contrast-enhanced endoscopic ultrasound (ch-eus) to guide the treatment choice in superficial rectal lesions: a case series
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341096/
https://www.ncbi.nlm.nih.gov/pubmed/37443660
http://dx.doi.org/10.3390/diagnostics13132267
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