Cargando…
Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications—Are We on the Road to Success?
Cardiovascular diseases (CVDs) are pointed out by the World Health Organization (WHO) as the leading cause of death, contributing to a significant and growing global health and economic burden. Despite advancements in clinical approaches, there is a critical need for innovative cardiovascular treatm...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341347/ https://www.ncbi.nlm.nih.gov/pubmed/37443761 http://dx.doi.org/10.3390/cells12131727 |
_version_ | 1785072240760455168 |
---|---|
author | Correia, Cátia D. Ferreira, Anita Fernandes, Mónica T. Silva, Bárbara M. Esteves, Filipa Leitão, Helena S. Bragança, José Calado, Sofia M. |
author_facet | Correia, Cátia D. Ferreira, Anita Fernandes, Mónica T. Silva, Bárbara M. Esteves, Filipa Leitão, Helena S. Bragança, José Calado, Sofia M. |
author_sort | Correia, Cátia D. |
collection | PubMed |
description | Cardiovascular diseases (CVDs) are pointed out by the World Health Organization (WHO) as the leading cause of death, contributing to a significant and growing global health and economic burden. Despite advancements in clinical approaches, there is a critical need for innovative cardiovascular treatments to improve patient outcomes. Therapies based on adult stem cells (ASCs) and embryonic stem cells (ESCs) have emerged as promising strategies to regenerate damaged cardiac tissue and restore cardiac function. Moreover, the generation of human induced pluripotent stem cells (iPSCs) from somatic cells has opened new avenues for disease modeling, drug discovery, and regenerative medicine applications, with fewer ethical concerns than those associated with ESCs. Herein, we provide a state-of-the-art review on the application of human pluripotent stem cells in CVD research and clinics. We describe the types and sources of stem cells that have been tested in preclinical and clinical trials for the treatment of CVDs as well as the applications of pluripotent stem-cell-derived in vitro systems to mimic disease phenotypes. How human stem-cell-based in vitro systems can overcome the limitations of current toxicological studies is also discussed. Finally, the current state of clinical trials involving stem-cell-based approaches to treat CVDs are presented, and the strengths and weaknesses are critically discussed to assess whether researchers and clinicians are getting closer to success. |
format | Online Article Text |
id | pubmed-10341347 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103413472023-07-14 Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications—Are We on the Road to Success? Correia, Cátia D. Ferreira, Anita Fernandes, Mónica T. Silva, Bárbara M. Esteves, Filipa Leitão, Helena S. Bragança, José Calado, Sofia M. Cells Review Cardiovascular diseases (CVDs) are pointed out by the World Health Organization (WHO) as the leading cause of death, contributing to a significant and growing global health and economic burden. Despite advancements in clinical approaches, there is a critical need for innovative cardiovascular treatments to improve patient outcomes. Therapies based on adult stem cells (ASCs) and embryonic stem cells (ESCs) have emerged as promising strategies to regenerate damaged cardiac tissue and restore cardiac function. Moreover, the generation of human induced pluripotent stem cells (iPSCs) from somatic cells has opened new avenues for disease modeling, drug discovery, and regenerative medicine applications, with fewer ethical concerns than those associated with ESCs. Herein, we provide a state-of-the-art review on the application of human pluripotent stem cells in CVD research and clinics. We describe the types and sources of stem cells that have been tested in preclinical and clinical trials for the treatment of CVDs as well as the applications of pluripotent stem-cell-derived in vitro systems to mimic disease phenotypes. How human stem-cell-based in vitro systems can overcome the limitations of current toxicological studies is also discussed. Finally, the current state of clinical trials involving stem-cell-based approaches to treat CVDs are presented, and the strengths and weaknesses are critically discussed to assess whether researchers and clinicians are getting closer to success. MDPI 2023-06-27 /pmc/articles/PMC10341347/ /pubmed/37443761 http://dx.doi.org/10.3390/cells12131727 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Correia, Cátia D. Ferreira, Anita Fernandes, Mónica T. Silva, Bárbara M. Esteves, Filipa Leitão, Helena S. Bragança, José Calado, Sofia M. Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications—Are We on the Road to Success? |
title | Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications—Are We on the Road to Success? |
title_full | Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications—Are We on the Road to Success? |
title_fullStr | Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications—Are We on the Road to Success? |
title_full_unstemmed | Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications—Are We on the Road to Success? |
title_short | Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications—Are We on the Road to Success? |
title_sort | human stem cells for cardiac disease modeling and preclinical and clinical applications—are we on the road to success? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341347/ https://www.ncbi.nlm.nih.gov/pubmed/37443761 http://dx.doi.org/10.3390/cells12131727 |
work_keys_str_mv | AT correiacatiad humanstemcellsforcardiacdiseasemodelingandpreclinicalandclinicalapplicationsareweontheroadtosuccess AT ferreiraanita humanstemcellsforcardiacdiseasemodelingandpreclinicalandclinicalapplicationsareweontheroadtosuccess AT fernandesmonicat humanstemcellsforcardiacdiseasemodelingandpreclinicalandclinicalapplicationsareweontheroadtosuccess AT silvabarbaram humanstemcellsforcardiacdiseasemodelingandpreclinicalandclinicalapplicationsareweontheroadtosuccess AT estevesfilipa humanstemcellsforcardiacdiseasemodelingandpreclinicalandclinicalapplicationsareweontheroadtosuccess AT leitaohelenas humanstemcellsforcardiacdiseasemodelingandpreclinicalandclinicalapplicationsareweontheroadtosuccess AT bragancajose humanstemcellsforcardiacdiseasemodelingandpreclinicalandclinicalapplicationsareweontheroadtosuccess AT caladosofiam humanstemcellsforcardiacdiseasemodelingandpreclinicalandclinicalapplicationsareweontheroadtosuccess |