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Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications—Are We on the Road to Success?

Cardiovascular diseases (CVDs) are pointed out by the World Health Organization (WHO) as the leading cause of death, contributing to a significant and growing global health and economic burden. Despite advancements in clinical approaches, there is a critical need for innovative cardiovascular treatm...

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Autores principales: Correia, Cátia D., Ferreira, Anita, Fernandes, Mónica T., Silva, Bárbara M., Esteves, Filipa, Leitão, Helena S., Bragança, José, Calado, Sofia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341347/
https://www.ncbi.nlm.nih.gov/pubmed/37443761
http://dx.doi.org/10.3390/cells12131727
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author Correia, Cátia D.
Ferreira, Anita
Fernandes, Mónica T.
Silva, Bárbara M.
Esteves, Filipa
Leitão, Helena S.
Bragança, José
Calado, Sofia M.
author_facet Correia, Cátia D.
Ferreira, Anita
Fernandes, Mónica T.
Silva, Bárbara M.
Esteves, Filipa
Leitão, Helena S.
Bragança, José
Calado, Sofia M.
author_sort Correia, Cátia D.
collection PubMed
description Cardiovascular diseases (CVDs) are pointed out by the World Health Organization (WHO) as the leading cause of death, contributing to a significant and growing global health and economic burden. Despite advancements in clinical approaches, there is a critical need for innovative cardiovascular treatments to improve patient outcomes. Therapies based on adult stem cells (ASCs) and embryonic stem cells (ESCs) have emerged as promising strategies to regenerate damaged cardiac tissue and restore cardiac function. Moreover, the generation of human induced pluripotent stem cells (iPSCs) from somatic cells has opened new avenues for disease modeling, drug discovery, and regenerative medicine applications, with fewer ethical concerns than those associated with ESCs. Herein, we provide a state-of-the-art review on the application of human pluripotent stem cells in CVD research and clinics. We describe the types and sources of stem cells that have been tested in preclinical and clinical trials for the treatment of CVDs as well as the applications of pluripotent stem-cell-derived in vitro systems to mimic disease phenotypes. How human stem-cell-based in vitro systems can overcome the limitations of current toxicological studies is also discussed. Finally, the current state of clinical trials involving stem-cell-based approaches to treat CVDs are presented, and the strengths and weaknesses are critically discussed to assess whether researchers and clinicians are getting closer to success.
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spelling pubmed-103413472023-07-14 Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications—Are We on the Road to Success? Correia, Cátia D. Ferreira, Anita Fernandes, Mónica T. Silva, Bárbara M. Esteves, Filipa Leitão, Helena S. Bragança, José Calado, Sofia M. Cells Review Cardiovascular diseases (CVDs) are pointed out by the World Health Organization (WHO) as the leading cause of death, contributing to a significant and growing global health and economic burden. Despite advancements in clinical approaches, there is a critical need for innovative cardiovascular treatments to improve patient outcomes. Therapies based on adult stem cells (ASCs) and embryonic stem cells (ESCs) have emerged as promising strategies to regenerate damaged cardiac tissue and restore cardiac function. Moreover, the generation of human induced pluripotent stem cells (iPSCs) from somatic cells has opened new avenues for disease modeling, drug discovery, and regenerative medicine applications, with fewer ethical concerns than those associated with ESCs. Herein, we provide a state-of-the-art review on the application of human pluripotent stem cells in CVD research and clinics. We describe the types and sources of stem cells that have been tested in preclinical and clinical trials for the treatment of CVDs as well as the applications of pluripotent stem-cell-derived in vitro systems to mimic disease phenotypes. How human stem-cell-based in vitro systems can overcome the limitations of current toxicological studies is also discussed. Finally, the current state of clinical trials involving stem-cell-based approaches to treat CVDs are presented, and the strengths and weaknesses are critically discussed to assess whether researchers and clinicians are getting closer to success. MDPI 2023-06-27 /pmc/articles/PMC10341347/ /pubmed/37443761 http://dx.doi.org/10.3390/cells12131727 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Correia, Cátia D.
Ferreira, Anita
Fernandes, Mónica T.
Silva, Bárbara M.
Esteves, Filipa
Leitão, Helena S.
Bragança, José
Calado, Sofia M.
Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications—Are We on the Road to Success?
title Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications—Are We on the Road to Success?
title_full Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications—Are We on the Road to Success?
title_fullStr Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications—Are We on the Road to Success?
title_full_unstemmed Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications—Are We on the Road to Success?
title_short Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications—Are We on the Road to Success?
title_sort human stem cells for cardiac disease modeling and preclinical and clinical applications—are we on the road to success?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341347/
https://www.ncbi.nlm.nih.gov/pubmed/37443761
http://dx.doi.org/10.3390/cells12131727
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