Extending AAV Packaging Cargo through Dual Co-Transduction: Efficient Protein Trans-Splicing at Low Vector Doses

Adeno-associated viral (AAV) vectors represent one of the leading platforms for gene delivery. Nevertheless, their small packaging capacity restricts their use for diseases requiring large-gene delivery. To overcome this, dual-AAV vector systems that rely on protein trans-splicing were developed, wi...

Descripción completa

Detalles Bibliográficos
Autores principales: Ferreira, Mariana V., Fernandes, Sofia, Almeida, Ana Isabel, Neto, Salomé, Mendes, João P., Silva, Ricardo J. S., Peixoto, Cristina, Coroadinha, Ana Sofia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341399/
https://www.ncbi.nlm.nih.gov/pubmed/37445701
http://dx.doi.org/10.3390/ijms241310524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341399/
https://www.ncbi.nlm.nih.gov/pubmed/37445701
http://dx.doi.org/10.3390/ijms241310524

Ejemplares similares