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Vomeronasal Receptors Associated with Circulating Estrogen Processing Chemosensory Cues in Semi-Aquatic Mammals

In numerous animals, one essential chemosensory organ that detects chemical signals is the vomeronasal organ (VNO), which is involved in species-specific behaviors, including social and sexual behaviors. The purpose of this study is to investigate the mechanism underlying the processing of chemosens...

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Autores principales: Xie, Wenqian, Chen, Meiqi, Shen, Yuyao, Liu, Yuning, Zhang, Haolin, Weng, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341468/
https://www.ncbi.nlm.nih.gov/pubmed/37445898
http://dx.doi.org/10.3390/ijms241310724
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author Xie, Wenqian
Chen, Meiqi
Shen, Yuyao
Liu, Yuning
Zhang, Haolin
Weng, Qiang
author_facet Xie, Wenqian
Chen, Meiqi
Shen, Yuyao
Liu, Yuning
Zhang, Haolin
Weng, Qiang
author_sort Xie, Wenqian
collection PubMed
description In numerous animals, one essential chemosensory organ that detects chemical signals is the vomeronasal organ (VNO), which is involved in species-specific behaviors, including social and sexual behaviors. The purpose of this study is to investigate the mechanism underlying the processing of chemosensory cues in semi-aquatic mammals using muskrats as the animal model. Muskrat (Ondatra zibethicus) has a sensitive VNO system that activates seasonal breeding behaviors through receiving specific substances, including pheromones and hormones. Vomeronasal organ receptor type 1 (V1R) and type 2 (V2R) and estrogen receptor α and β (ERα and ERβ) were found in sensory epithelial cells, non-sensory epithelial cells and lamina propria cells of the female muskrats’ VNO. V2R and ERα mRNA levels in the VNO during the breeding period declined sharply, in comparison to those during the non-breeding period, while V1R and ERβ mRNA levels were detected reversely. Additionally, transcriptomic study in the VNO identified that differently expressed genes might be related to estrogen signal and metabolic pathways. These findings suggested that the seasonal structural and functional changes in the VNO of female muskrats with different reproductive status and estrogen was regulated through binding to ERα and ERβ in the female muskrats’ VNO.
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spelling pubmed-103414682023-07-14 Vomeronasal Receptors Associated with Circulating Estrogen Processing Chemosensory Cues in Semi-Aquatic Mammals Xie, Wenqian Chen, Meiqi Shen, Yuyao Liu, Yuning Zhang, Haolin Weng, Qiang Int J Mol Sci Article In numerous animals, one essential chemosensory organ that detects chemical signals is the vomeronasal organ (VNO), which is involved in species-specific behaviors, including social and sexual behaviors. The purpose of this study is to investigate the mechanism underlying the processing of chemosensory cues in semi-aquatic mammals using muskrats as the animal model. Muskrat (Ondatra zibethicus) has a sensitive VNO system that activates seasonal breeding behaviors through receiving specific substances, including pheromones and hormones. Vomeronasal organ receptor type 1 (V1R) and type 2 (V2R) and estrogen receptor α and β (ERα and ERβ) were found in sensory epithelial cells, non-sensory epithelial cells and lamina propria cells of the female muskrats’ VNO. V2R and ERα mRNA levels in the VNO during the breeding period declined sharply, in comparison to those during the non-breeding period, while V1R and ERβ mRNA levels were detected reversely. Additionally, transcriptomic study in the VNO identified that differently expressed genes might be related to estrogen signal and metabolic pathways. These findings suggested that the seasonal structural and functional changes in the VNO of female muskrats with different reproductive status and estrogen was regulated through binding to ERα and ERβ in the female muskrats’ VNO. MDPI 2023-06-27 /pmc/articles/PMC10341468/ /pubmed/37445898 http://dx.doi.org/10.3390/ijms241310724 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xie, Wenqian
Chen, Meiqi
Shen, Yuyao
Liu, Yuning
Zhang, Haolin
Weng, Qiang
Vomeronasal Receptors Associated with Circulating Estrogen Processing Chemosensory Cues in Semi-Aquatic Mammals
title Vomeronasal Receptors Associated with Circulating Estrogen Processing Chemosensory Cues in Semi-Aquatic Mammals
title_full Vomeronasal Receptors Associated with Circulating Estrogen Processing Chemosensory Cues in Semi-Aquatic Mammals
title_fullStr Vomeronasal Receptors Associated with Circulating Estrogen Processing Chemosensory Cues in Semi-Aquatic Mammals
title_full_unstemmed Vomeronasal Receptors Associated with Circulating Estrogen Processing Chemosensory Cues in Semi-Aquatic Mammals
title_short Vomeronasal Receptors Associated with Circulating Estrogen Processing Chemosensory Cues in Semi-Aquatic Mammals
title_sort vomeronasal receptors associated with circulating estrogen processing chemosensory cues in semi-aquatic mammals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341468/
https://www.ncbi.nlm.nih.gov/pubmed/37445898
http://dx.doi.org/10.3390/ijms241310724
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