Immunotherapeutic Approaches for the Treatment of Glioblastoma Multiforme: Mechanism and Clinical Applications

Glioma is one of the most aggressive types of primary brain tumor with a high-grade glioma known as glioblastoma multiforme (GBM). Patients diagnosed with GBM usually have an overall survival rate of less than 18 months after conventional therapy. This bleak prognosis underlines the need to consider...

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Autores principales: Das, Suprava, Dash, Banendu Sunder, Premji, Thejas P., Chen, Jyh-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341481/
https://www.ncbi.nlm.nih.gov/pubmed/37445721
http://dx.doi.org/10.3390/ijms241310546
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author Das, Suprava
Dash, Banendu Sunder
Premji, Thejas P.
Chen, Jyh-Ping
author_facet Das, Suprava
Dash, Banendu Sunder
Premji, Thejas P.
Chen, Jyh-Ping
author_sort Das, Suprava
collection PubMed
description Glioma is one of the most aggressive types of primary brain tumor with a high-grade glioma known as glioblastoma multiforme (GBM). Patients diagnosed with GBM usually have an overall survival rate of less than 18 months after conventional therapy. This bleak prognosis underlines the need to consider new therapeutic interventions for GBM treatment to overcome current treatment limitations. By highlighting different immunotherapeutic approaches currently in preclinical and clinical trials, including immune checkpoint inhibitors, chimeric antigen receptors T cells, natural killer cells, vaccines, and combination therapy, this review aims to discuss the mechanisms, benefits, and limitations of immunotherapy in treating GBM patients.
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spelling pubmed-103414812023-07-14 Immunotherapeutic Approaches for the Treatment of Glioblastoma Multiforme: Mechanism and Clinical Applications Das, Suprava Dash, Banendu Sunder Premji, Thejas P. Chen, Jyh-Ping Int J Mol Sci Review Glioma is one of the most aggressive types of primary brain tumor with a high-grade glioma known as glioblastoma multiforme (GBM). Patients diagnosed with GBM usually have an overall survival rate of less than 18 months after conventional therapy. This bleak prognosis underlines the need to consider new therapeutic interventions for GBM treatment to overcome current treatment limitations. By highlighting different immunotherapeutic approaches currently in preclinical and clinical trials, including immune checkpoint inhibitors, chimeric antigen receptors T cells, natural killer cells, vaccines, and combination therapy, this review aims to discuss the mechanisms, benefits, and limitations of immunotherapy in treating GBM patients. MDPI 2023-06-23 /pmc/articles/PMC10341481/ /pubmed/37445721 http://dx.doi.org/10.3390/ijms241310546 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Das, Suprava
Dash, Banendu Sunder
Premji, Thejas P.
Chen, Jyh-Ping
Immunotherapeutic Approaches for the Treatment of Glioblastoma Multiforme: Mechanism and Clinical Applications
title Immunotherapeutic Approaches for the Treatment of Glioblastoma Multiforme: Mechanism and Clinical Applications
title_full Immunotherapeutic Approaches for the Treatment of Glioblastoma Multiforme: Mechanism and Clinical Applications
title_fullStr Immunotherapeutic Approaches for the Treatment of Glioblastoma Multiforme: Mechanism and Clinical Applications
title_full_unstemmed Immunotherapeutic Approaches for the Treatment of Glioblastoma Multiforme: Mechanism and Clinical Applications
title_short Immunotherapeutic Approaches for the Treatment of Glioblastoma Multiforme: Mechanism and Clinical Applications
title_sort immunotherapeutic approaches for the treatment of glioblastoma multiforme: mechanism and clinical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341481/
https://www.ncbi.nlm.nih.gov/pubmed/37445721
http://dx.doi.org/10.3390/ijms241310546
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