Transcriptional and Histone Acetylation Changes Associated with CRE Elements Expose Key Factors Governing the Regulatory Circuit in the Early Stage of Huntington’s Disease Models

Huntington’s disease (HD) is a disorder caused by an abnormal expansion of trinucleotide CAG repeats within the huntingtin (Htt) gene. Under normal conditions, the CREB Binding Protein interacts with CREB elements and acetylates Lysine 27 of Histone 3 to direct the expression of several genes. Howev...

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Detalles Bibliográficos
Autores principales: Arancibia-Opazo, Sandra, Contreras-Riquelme, J. Sebastián, Sánchez, Mario, Cisternas-Olmedo, Marisol, Vidal, René L., Martin, Alberto J. M., Sáez, Mauricio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341483/
https://www.ncbi.nlm.nih.gov/pubmed/37446028
http://dx.doi.org/10.3390/ijms241310848

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