Cargando…

New Efforts to Demonstrate the Successful Use of TRH as a Therapeutic Agent

Thyrotropin-releasing hormone (TRH) is a tripeptide that regulates the neuroendocrine thyroid axis. Moreover, its widespread brain distribution has indicated that it is a relevant neuromodulator of behaviors such as feeding, arousal, anxiety, and locomotion. Importantly, it is also a neurotrophic pe...

Descripción completa

Detalles Bibliográficos
Autores principales: Alvarez-Salas, Elena, García-Luna, Cinthia, de Gortari, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341491/
https://www.ncbi.nlm.nih.gov/pubmed/37446225
http://dx.doi.org/10.3390/ijms241311047
_version_ 1785072274680840192
author Alvarez-Salas, Elena
García-Luna, Cinthia
de Gortari, Patricia
author_facet Alvarez-Salas, Elena
García-Luna, Cinthia
de Gortari, Patricia
author_sort Alvarez-Salas, Elena
collection PubMed
description Thyrotropin-releasing hormone (TRH) is a tripeptide that regulates the neuroendocrine thyroid axis. Moreover, its widespread brain distribution has indicated that it is a relevant neuromodulator of behaviors such as feeding, arousal, anxiety, and locomotion. Importantly, it is also a neurotrophic peptide, and thus may halt the development of neurodegenerative diseases and improve mood-related disorders. Its neuroprotective actions on those pathologies and behaviors have been limited due to its poor intestinal and blood–brain barrier permeability, and because it is rapidly degraded by a serum enzyme. As new strategies such as TRH intranasal delivery emerge, a renewed interest in the peptide has arisen. TRH analogs have proven to be safe in animals and humans, while not inducing alterations in thyroid hormones’ levels. In this review, we integrate research from different approaches, aiming to demonstrate the therapeutic effects of TRH, and to summarize new efforts to prolong and facilitate the peptide’s actions to improve symptoms and the progression of several pathologies.
format Online
Article
Text
id pubmed-10341491
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103414912023-07-14 New Efforts to Demonstrate the Successful Use of TRH as a Therapeutic Agent Alvarez-Salas, Elena García-Luna, Cinthia de Gortari, Patricia Int J Mol Sci Review Thyrotropin-releasing hormone (TRH) is a tripeptide that regulates the neuroendocrine thyroid axis. Moreover, its widespread brain distribution has indicated that it is a relevant neuromodulator of behaviors such as feeding, arousal, anxiety, and locomotion. Importantly, it is also a neurotrophic peptide, and thus may halt the development of neurodegenerative diseases and improve mood-related disorders. Its neuroprotective actions on those pathologies and behaviors have been limited due to its poor intestinal and blood–brain barrier permeability, and because it is rapidly degraded by a serum enzyme. As new strategies such as TRH intranasal delivery emerge, a renewed interest in the peptide has arisen. TRH analogs have proven to be safe in animals and humans, while not inducing alterations in thyroid hormones’ levels. In this review, we integrate research from different approaches, aiming to demonstrate the therapeutic effects of TRH, and to summarize new efforts to prolong and facilitate the peptide’s actions to improve symptoms and the progression of several pathologies. MDPI 2023-07-04 /pmc/articles/PMC10341491/ /pubmed/37446225 http://dx.doi.org/10.3390/ijms241311047 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Alvarez-Salas, Elena
García-Luna, Cinthia
de Gortari, Patricia
New Efforts to Demonstrate the Successful Use of TRH as a Therapeutic Agent
title New Efforts to Demonstrate the Successful Use of TRH as a Therapeutic Agent
title_full New Efforts to Demonstrate the Successful Use of TRH as a Therapeutic Agent
title_fullStr New Efforts to Demonstrate the Successful Use of TRH as a Therapeutic Agent
title_full_unstemmed New Efforts to Demonstrate the Successful Use of TRH as a Therapeutic Agent
title_short New Efforts to Demonstrate the Successful Use of TRH as a Therapeutic Agent
title_sort new efforts to demonstrate the successful use of trh as a therapeutic agent
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341491/
https://www.ncbi.nlm.nih.gov/pubmed/37446225
http://dx.doi.org/10.3390/ijms241311047
work_keys_str_mv AT alvarezsalaselena neweffortstodemonstratethesuccessfuluseoftrhasatherapeuticagent
AT garcialunacinthia neweffortstodemonstratethesuccessfuluseoftrhasatherapeuticagent
AT degortaripatricia neweffortstodemonstratethesuccessfuluseoftrhasatherapeuticagent