The Oral Transglutaminase 2 Inhibitor ZED1227 Accumulates in the Villous Enterocytes in Celiac Disease Patients during Gluten Challenge and Drug Treatment

The enzyme transglutaminase 2 (TG2) plays a key role in celiac disease (CeD) pathogenesis. Active TG2 is located mainly extracellularly in the lamina propria but also in the villous enterocytes of the duodenum. The TG2 inhibitor ZED1227 is a promising drug candidate for treating CeD and is designed...

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Detalles Bibliográficos
Autores principales: Isola, Jorma, Mäki, Markku, Hils, Martin, Pasternack, Ralf, Viiri, Keijo, Dotsenko, Valeriia, Montonen, Toni, Zimmermann, Timo, Mohrbacher, Ralf, Greinwald, Roland, Schuppan, Detlef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341493/
https://www.ncbi.nlm.nih.gov/pubmed/37445994
http://dx.doi.org/10.3390/ijms241310815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341493/
https://www.ncbi.nlm.nih.gov/pubmed/37445994
http://dx.doi.org/10.3390/ijms241310815

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