Cargando…

Transcriptomic Analysis Reveals the Inability of Recombinant AAV8 to Activate Human Monocyte-Derived Dendritic Cells

Recombinant Adeno-Associated Virus (rAAV) is considered as one of the most successful and widely used viral vectors for in vivo gene therapy. However, host immune responses to the vector and/or the transgene product remain a major hurdle to successful AAV gene transfer. In contrast to antivector ada...

Descripción completa

Detalles Bibliográficos
Autores principales:	Masri, Samer, Carré, Laure, Jaulin, Nicolas, Vandamme, Céline, Couzinié, Célia, Guy-Duché, Aurélien, Dupont, Jean-Baptiste, Pereira, Allwyn, Charpentier, Eric, David, Laurent, Gernoux, Gwladys, Guilbaud, Mickaël, Adjali, Oumeya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341499/ https://www.ncbi.nlm.nih.gov/pubmed/37445621 http://dx.doi.org/10.3390/ijms241310447

Ejemplares similares

Tetramer-Based Enrichment of Preexisting Anti-AAV8 CD8(+) T Cells in Human Donors Allows the Detection of a T(EMRA) Subpopulation
por: Vandamme, Céline, et al.
Publicado: (2020)

AAV8 locoregional delivery induces long-term expression of an immunogenic transgene in macaques despite persisting local inflammation
por: Gernoux, Gwladys, et al.
Publicado: (2021)

Unraveling the Complex Story of Immune Responses to AAV Vectors Trial After Trial
por: Vandamme, Céline, et al.
Publicado: (2017)

Generation and in vivo evaluation of IL10-treated dendritic cells in a nonhuman primate model of AAV-based gene transfer
por: Moreau, Aurélie, et al.
Publicado: (2014)

Transgene Regulation Using the Tetracycline-Inducible TetR-KRAB System after AAV-Mediated Gene Transfer in Rodents and Nonhuman Primates
por: Le Guiner, Caroline, et al.
Publicado: (2014)

Cross-Packaging and Capsid Mosaic Formation in Multiplexed AAV Libraries
por: Schmit, Pauline F., et al.
Publicado: (2019)

Intrathymic AAV delivery results in therapeutic site-specific integration at TCR loci in mice
por: Calabria, Andrea, et al.
Publicado: (2023)

Muscle-Directed Delivery of an AAV1 Vector Leads to Capsid-Specific T Cell Exhaustion in Nonhuman Primates and Humans
por: Gernoux, Gwladys, et al.
Publicado: (2020)

Accurate Titration of Infectious AAV Particles Requires Measurement of Biologically Active Vector Genomes and Suitable Controls
por: François, Achille, et al.
Publicado: (2018)

Intravitreal air tamponade after AAV2 subretinal injection modifies retinal EGFP distribution
por: Ducloyer, Jean-Baptiste, et al.
Publicado: (2023)

Intra-CSF AAV9 and AAVrh10 Administration in Nonhuman Primates: Promising Routes and Vectors for Which Neurological Diseases?
por: Bey, Karim, et al.
Publicado: (2020)

Risk Mitigation of Immunogenicity: A Key to Personalized Retinal Gene Therapy
por: Varin, Juliette, et al.
Publicado: (2021)

Evaluation of an AAV9-mini-dystrophin gene therapy candidate in a rat model of Duchenne muscular dystrophy
por: Le Guiner, Caroline, et al.
Publicado: (2023)

Bridging from Intramuscular to Limb Perfusion Delivery of rAAV: Optimization in a Non-human Primate Study
por: Gruntman, Alisha M., et al.
Publicado: (2019)

Inability and Obligation in Moral Judgment
por: Buckwalter, Wesley, et al.
Publicado: (2015)

Inability to Culture Pneumocystis jirovecii
por: Liu, Yueqin, et al.
Publicado: (2018)

Syncope and the Inability to Move: Was It the Magnesium?
por: Perkins, David R, et al.
Publicado: (2023)

Pelvic Abscess with Presentation as Inability to Ambulate
por: Damer, Sarah A.
Publicado: (2017)

Infant with inability to abduct left eye
por: Dodderer, Joshua K., et al.
Publicado: (2021)

Vascular Delivery of Allogeneic MuStem Cells in Dystrophic Dogs Requires Only Short-Term Immunosuppression to Avoid Host Immunity and Generate Clinical/Tissue Benefits
por: Lorant, Judith, et al.
Publicado: (2018)

Chemical modification of the adeno-associated virus capsid to improve gene delivery
por: Mével, Mathieu, et al.
Publicado: (2019)

Immunity over inability: The spontaneous regression of cancer
por: Jessy, Thomas
Publicado: (2011)

Depression Treatment with Duloxetine and Reduction of Inability to Work
por: Happich, Michael, et al.
Publicado: (2012)

Remarks on the Inability to Produce the Effect of Emetics in Horses
por: Hargrove, George
Publicado: (1810)

A Rare Case Involving the Inability to Belch
por: Sato, Hiroki, et al.
Publicado: (2018)

Congenital Word Blindness, or Inability to Learn to Read
por: Clemesha, John C.
Publicado: (1914)

Liver-Specific Transcriptional Modules Identified by Genome-Wide In Silico Analysis Enable Efficient Gene Therapy in Mice and Non-Human Primates
por: Chuah, Marinee K, et al.
Publicado: (2014)

Inability to Ventilate after Tube Exchange Postoperative to Pneumonectomy
por: Verstraeten, S. E., et al.
Publicado: (2012)

Inability to walk due to scurvy: a forgotten disease
por: Algahtani, Hussein A., et al.
Publicado: (2010)

Inability of field theory to exploit the full unitarity condition
por: Martin, A
Publicado: (1966)

Inability to walk: a rare presentation of Crohn’s disease
por: Hoekstra, Elmer, et al.
Publicado: (2020)

Liver-directed SERPINA1 gene therapy attenuates progression of spontaneous and tobacco smoke-induced emphysema in α1-antitrypsin null mice
por: Zieger, Marina, et al.
Publicado: (2022)

445 Inability of Medical Students to Use of Three Types of Inhaler
por: Jeong, Jae-Won
Publicado: (2012)

Inability of Some Commercial Assays to Measure Suppression of Glucagon Secretion
por: Wewer Albrechtsen, Nicolai J., et al.
Publicado: (2016)

Inability of Physicians and Nurses to Predict Patient Satisfaction in the Emergency Department
por: DeLaney, Matthew C., et al.
Publicado: (2015)

Reply to Liu et al., “Inability To Culture Pneumocystis jirovecii”
por: Schildgen, Verena, et al.
Publicado: (2018)

Hand–foot motor priming in the presence of temporary inability to use hands
por: Craighero, Laila, et al.
Publicado: (2012)

Inability to predict postpartum hemorrhage: insights from Egyptian intervention data
por: Prata, Ndola, et al.
Publicado: (2011)

Inability to Reverse Aspirin and Clopidogrel-induced Platelet Dysfunction with Platelet Infusion
por: Cohn, Stephen M, et al.
Publicado: (2019)

Inability to Walk Predicts Death among Adult Patients in Hospitals in Malawi
por: Kayambankadzanja, Raphael Kazidule, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_cfsi9erkmr5fc13jah81des04h