Selective Killing of BRCA2-Deficient Ovarian Cancer Cells via MRE11 Blockade

The MRE11 nuclease is essential during DNA damage recognition, homologous recombination, and replication. BRCA2 plays important roles during homologous recombination and replication. Here, we show that effecting an MRE11 blockade using a prototypical inhibitor (Mirin) induces synthetic lethality (SL...

Descripción completa

Detalles Bibliográficos
Autores principales: Alblihy, Adel, Ali, Reem, Algethami, Mashael, Ritchie, Alison A., Shoqafi, Ahmed, Alqahtani, Shatha, Mesquita, Katia A., Toss, Michael S., Ordóñez-Morán, Paloma, Jeyapalan, Jennie N., Dekker, Lodewijk, Salerno, Martina, Hartsuiker, Edgar, Grabowska, Anna M., Rakha, Emad A., Mongan, Nigel P., Madhusudan, Srinivasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341502/
https://www.ncbi.nlm.nih.gov/pubmed/37446144
http://dx.doi.org/10.3390/ijms241310966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341502/
https://www.ncbi.nlm.nih.gov/pubmed/37446144
http://dx.doi.org/10.3390/ijms241310966

Ejemplares similares