Genetic Ablation of Inositol 1,4,5-Trisphosphate Receptor Type 2 (IP(3)R2) Fails to Modify Disease Progression in a Mouse Model of Spinocerebellar Ataxia Type 3

Spinocerebellar ataxia type 3 (SCA3) is a rare neurodegenerative disease caused by an abnormal polyglutamine expansion within the ataxin-3 protein (ATXN3). This leads to neurodegeneration of specific brain and spinal cord regions, resulting in a progressive loss of motor function. Despite neuronal d...

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Detalles Bibliográficos
Autores principales: Cunha-Garcia, Daniela, Monteiro-Fernandes, Daniela, Correia, Joana Sofia, Neves-Carvalho, Andreia, Vilaça-Ferreira, Ana Catarina, Guerra-Gomes, Sónia, Viana, João Filipe, Oliveira, João Filipe, Teixeira-Castro, Andreia, Maciel, Patrícia, Duarte-Silva, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341520/
https://www.ncbi.nlm.nih.gov/pubmed/37445783
http://dx.doi.org/10.3390/ijms241310606

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