Beta-Secretase 1 Recruits Amyloid-Beta Precursor Protein to ROCK2 Kinase, Resulting in Erroneous Phosphorylation and Beta-Amyloid Plaque Formation

The amyloidogenic processing of APP depends on two events: its phosphorylation by ROCK2 (at Thr654) and the phosphorylation of the APP-cleaving enzyme BACE1 (at Ser498). However, the mechanisms and structural details of APP-ROCK2 and BACE1-ROCK2 binding are unknown. Using direct physical methods in...

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Detalles Bibliográficos
Autores principales: Hajdú, István, Végh, Barbara M., Szilágyi, András, Závodszky, Péter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341550/
https://www.ncbi.nlm.nih.gov/pubmed/37445593
http://dx.doi.org/10.3390/ijms241310416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341550/
https://www.ncbi.nlm.nih.gov/pubmed/37445593
http://dx.doi.org/10.3390/ijms241310416

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