Design, Synthesis, and Biological Evaluation of Novel Quinazolin-4(3H)-One-Based Histone Deacetylase 6 (HDAC6) Inhibitors for Anticancer Activity

A series of novel quinazoline-4-(3H)-one derivatives were designed and synthesized as histone deacetylase 6 (HDAC6) inhibitors based on novel quinazoline-4-(3H)-one as the cap group and benzhydroxamic acid as the linker and metal-binding group. A total of 19 novel quinazoline-4-(3H)-one analogues (5...

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Detalles Bibliográficos
Autores principales: Khetmalis, Yogesh Mahadu, Fathima, Ashna, Schweipert, Markus, Debarnot, Cécile, Bandaru, Naga Venkata Madhusudhan Rao, Murugesan, Sankaranarayanan, Jamma, Trinath, Meyer-Almes, Franz-Josef, Sekhar, Kondapalli Venkata Gowri Chandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341573/
https://www.ncbi.nlm.nih.gov/pubmed/37446224
http://dx.doi.org/10.3390/ijms241311044

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