Cargando…
Monocytes in the Characterization of Pain in Palliative Patients with Severe Dementia—A Pilot Study
In assessing and managing pain, when obtaining a self-report is impossible, therapeutic decision-making becomes more challenging. This study aimed to investigate whether monocytes and some membrane monocyte proteins, identified as a cluster of differentiation (CD), could be potential non-invasive pe...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341601/ https://www.ncbi.nlm.nih.gov/pubmed/37445910 http://dx.doi.org/10.3390/ijms241310723 |
_version_ | 1785072300569133056 |
---|---|
author | Ribeiro, Hugo Alves, Raquel Jorge, Joana Gonçalves, Ana Cristina Sarmento-Ribeiro, Ana Bela Teixeira-Veríssimo, Manuel Andrade, José Paulo Dourado, Marília |
author_facet | Ribeiro, Hugo Alves, Raquel Jorge, Joana Gonçalves, Ana Cristina Sarmento-Ribeiro, Ana Bela Teixeira-Veríssimo, Manuel Andrade, José Paulo Dourado, Marília |
author_sort | Ribeiro, Hugo |
collection | PubMed |
description | In assessing and managing pain, when obtaining a self-report is impossible, therapeutic decision-making becomes more challenging. This study aimed to investigate whether monocytes and some membrane monocyte proteins, identified as a cluster of differentiation (CD), could be potential non-invasive peripheral biomarkers in identifying and characterizing pain in patients with severe dementia. We used 53 blood samples from non-oncological palliative patients, 44 patients with pain (38 of whom had dementia) and 0 without pain or dementia (controls). We evaluated the levels of monocytes and their subtypes, including classic, intermediate, and non-classic, and characterized the levels of specific phenotypic markers, namely CD11c, CD86, CD163, and CD206. We found that the relative concentrations of monocytes, particularly the percentage of classic monocytes, may be a helpful pain biomarker. Furthermore, the CD11c expression levels were significantly higher in patients with mixed pain, while CD163 and CD206 expression levels were significantly higher in patients with nociceptive pain. These findings suggest that the levels of monocytes, particularly the classic subtype, and their phenotype markers CD11c, CD163, and CD206 could serve as pain biomarkers in patients with severe dementia. |
format | Online Article Text |
id | pubmed-10341601 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103416012023-07-14 Monocytes in the Characterization of Pain in Palliative Patients with Severe Dementia—A Pilot Study Ribeiro, Hugo Alves, Raquel Jorge, Joana Gonçalves, Ana Cristina Sarmento-Ribeiro, Ana Bela Teixeira-Veríssimo, Manuel Andrade, José Paulo Dourado, Marília Int J Mol Sci Article In assessing and managing pain, when obtaining a self-report is impossible, therapeutic decision-making becomes more challenging. This study aimed to investigate whether monocytes and some membrane monocyte proteins, identified as a cluster of differentiation (CD), could be potential non-invasive peripheral biomarkers in identifying and characterizing pain in patients with severe dementia. We used 53 blood samples from non-oncological palliative patients, 44 patients with pain (38 of whom had dementia) and 0 without pain or dementia (controls). We evaluated the levels of monocytes and their subtypes, including classic, intermediate, and non-classic, and characterized the levels of specific phenotypic markers, namely CD11c, CD86, CD163, and CD206. We found that the relative concentrations of monocytes, particularly the percentage of classic monocytes, may be a helpful pain biomarker. Furthermore, the CD11c expression levels were significantly higher in patients with mixed pain, while CD163 and CD206 expression levels were significantly higher in patients with nociceptive pain. These findings suggest that the levels of monocytes, particularly the classic subtype, and their phenotype markers CD11c, CD163, and CD206 could serve as pain biomarkers in patients with severe dementia. MDPI 2023-06-27 /pmc/articles/PMC10341601/ /pubmed/37445910 http://dx.doi.org/10.3390/ijms241310723 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ribeiro, Hugo Alves, Raquel Jorge, Joana Gonçalves, Ana Cristina Sarmento-Ribeiro, Ana Bela Teixeira-Veríssimo, Manuel Andrade, José Paulo Dourado, Marília Monocytes in the Characterization of Pain in Palliative Patients with Severe Dementia—A Pilot Study |
title | Monocytes in the Characterization of Pain in Palliative Patients with Severe Dementia—A Pilot Study |
title_full | Monocytes in the Characterization of Pain in Palliative Patients with Severe Dementia—A Pilot Study |
title_fullStr | Monocytes in the Characterization of Pain in Palliative Patients with Severe Dementia—A Pilot Study |
title_full_unstemmed | Monocytes in the Characterization of Pain in Palliative Patients with Severe Dementia—A Pilot Study |
title_short | Monocytes in the Characterization of Pain in Palliative Patients with Severe Dementia—A Pilot Study |
title_sort | monocytes in the characterization of pain in palliative patients with severe dementia—a pilot study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341601/ https://www.ncbi.nlm.nih.gov/pubmed/37445910 http://dx.doi.org/10.3390/ijms241310723 |
work_keys_str_mv | AT ribeirohugo monocytesinthecharacterizationofpaininpalliativepatientswithseveredementiaapilotstudy AT alvesraquel monocytesinthecharacterizationofpaininpalliativepatientswithseveredementiaapilotstudy AT jorgejoana monocytesinthecharacterizationofpaininpalliativepatientswithseveredementiaapilotstudy AT goncalvesanacristina monocytesinthecharacterizationofpaininpalliativepatientswithseveredementiaapilotstudy AT sarmentoribeiroanabela monocytesinthecharacterizationofpaininpalliativepatientswithseveredementiaapilotstudy AT teixeiraverissimomanuel monocytesinthecharacterizationofpaininpalliativepatientswithseveredementiaapilotstudy AT andradejosepaulo monocytesinthecharacterizationofpaininpalliativepatientswithseveredementiaapilotstudy AT douradomarilia monocytesinthecharacterizationofpaininpalliativepatientswithseveredementiaapilotstudy |