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Monocytes in the Characterization of Pain in Palliative Patients with Severe Dementia—A Pilot Study

In assessing and managing pain, when obtaining a self-report is impossible, therapeutic decision-making becomes more challenging. This study aimed to investigate whether monocytes and some membrane monocyte proteins, identified as a cluster of differentiation (CD), could be potential non-invasive pe...

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Autores principales: Ribeiro, Hugo, Alves, Raquel, Jorge, Joana, Gonçalves, Ana Cristina, Sarmento-Ribeiro, Ana Bela, Teixeira-Veríssimo, Manuel, Andrade, José Paulo, Dourado, Marília
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341601/
https://www.ncbi.nlm.nih.gov/pubmed/37445910
http://dx.doi.org/10.3390/ijms241310723
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author Ribeiro, Hugo
Alves, Raquel
Jorge, Joana
Gonçalves, Ana Cristina
Sarmento-Ribeiro, Ana Bela
Teixeira-Veríssimo, Manuel
Andrade, José Paulo
Dourado, Marília
author_facet Ribeiro, Hugo
Alves, Raquel
Jorge, Joana
Gonçalves, Ana Cristina
Sarmento-Ribeiro, Ana Bela
Teixeira-Veríssimo, Manuel
Andrade, José Paulo
Dourado, Marília
author_sort Ribeiro, Hugo
collection PubMed
description In assessing and managing pain, when obtaining a self-report is impossible, therapeutic decision-making becomes more challenging. This study aimed to investigate whether monocytes and some membrane monocyte proteins, identified as a cluster of differentiation (CD), could be potential non-invasive peripheral biomarkers in identifying and characterizing pain in patients with severe dementia. We used 53 blood samples from non-oncological palliative patients, 44 patients with pain (38 of whom had dementia) and 0 without pain or dementia (controls). We evaluated the levels of monocytes and their subtypes, including classic, intermediate, and non-classic, and characterized the levels of specific phenotypic markers, namely CD11c, CD86, CD163, and CD206. We found that the relative concentrations of monocytes, particularly the percentage of classic monocytes, may be a helpful pain biomarker. Furthermore, the CD11c expression levels were significantly higher in patients with mixed pain, while CD163 and CD206 expression levels were significantly higher in patients with nociceptive pain. These findings suggest that the levels of monocytes, particularly the classic subtype, and their phenotype markers CD11c, CD163, and CD206 could serve as pain biomarkers in patients with severe dementia.
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spelling pubmed-103416012023-07-14 Monocytes in the Characterization of Pain in Palliative Patients with Severe Dementia—A Pilot Study Ribeiro, Hugo Alves, Raquel Jorge, Joana Gonçalves, Ana Cristina Sarmento-Ribeiro, Ana Bela Teixeira-Veríssimo, Manuel Andrade, José Paulo Dourado, Marília Int J Mol Sci Article In assessing and managing pain, when obtaining a self-report is impossible, therapeutic decision-making becomes more challenging. This study aimed to investigate whether monocytes and some membrane monocyte proteins, identified as a cluster of differentiation (CD), could be potential non-invasive peripheral biomarkers in identifying and characterizing pain in patients with severe dementia. We used 53 blood samples from non-oncological palliative patients, 44 patients with pain (38 of whom had dementia) and 0 without pain or dementia (controls). We evaluated the levels of monocytes and their subtypes, including classic, intermediate, and non-classic, and characterized the levels of specific phenotypic markers, namely CD11c, CD86, CD163, and CD206. We found that the relative concentrations of monocytes, particularly the percentage of classic monocytes, may be a helpful pain biomarker. Furthermore, the CD11c expression levels were significantly higher in patients with mixed pain, while CD163 and CD206 expression levels were significantly higher in patients with nociceptive pain. These findings suggest that the levels of monocytes, particularly the classic subtype, and their phenotype markers CD11c, CD163, and CD206 could serve as pain biomarkers in patients with severe dementia. MDPI 2023-06-27 /pmc/articles/PMC10341601/ /pubmed/37445910 http://dx.doi.org/10.3390/ijms241310723 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ribeiro, Hugo
Alves, Raquel
Jorge, Joana
Gonçalves, Ana Cristina
Sarmento-Ribeiro, Ana Bela
Teixeira-Veríssimo, Manuel
Andrade, José Paulo
Dourado, Marília
Monocytes in the Characterization of Pain in Palliative Patients with Severe Dementia—A Pilot Study
title Monocytes in the Characterization of Pain in Palliative Patients with Severe Dementia—A Pilot Study
title_full Monocytes in the Characterization of Pain in Palliative Patients with Severe Dementia—A Pilot Study
title_fullStr Monocytes in the Characterization of Pain in Palliative Patients with Severe Dementia—A Pilot Study
title_full_unstemmed Monocytes in the Characterization of Pain in Palliative Patients with Severe Dementia—A Pilot Study
title_short Monocytes in the Characterization of Pain in Palliative Patients with Severe Dementia—A Pilot Study
title_sort monocytes in the characterization of pain in palliative patients with severe dementia—a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341601/
https://www.ncbi.nlm.nih.gov/pubmed/37445910
http://dx.doi.org/10.3390/ijms241310723
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