Inhibition of Pertussis Toxin by Human α-Defensins-1 and -5: Differential Mechanisms of Action

Whooping cough is a severe childhood disease, caused by the bacterium Bordetella pertussis, which releases pertussis toxin (PT) as a major virulence factor. Previously, we identified the human antimicrobial peptides α-defensin-1 and -5 as inhibitors of PT and demonstrated their capacity to inhibit t...

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Detalles Bibliográficos
Autores principales: Kling, Carolin, Sommer, Anja, Almeida-Hernandez, Yasser, Rodríguez, Armando, Perez-Erviti, Julio A., Bhadane, Rajendra, Ständker, Ludger, Wiese, Sebastian, Barth, Holger, Pupo-Meriño, Mario, Pulliainen, Arto T., Sánchez-García, Elsa, Ernst, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341622/
https://www.ncbi.nlm.nih.gov/pubmed/37445740
http://dx.doi.org/10.3390/ijms241310557

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