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Anti-Inflammatory Effects of Nutritionally Relevant Concentrations of Oleuropein and Hydroxytyrosol on Peripheral Blood Mononuclear Cells: An Age-Related Analysis
Immunosenescence and inflammaging facilitate the insurgence of chronic diseases. The Mediterranean diet is a non-invasive intervention to improve the chronic low-grade inflammatory status associated with aging. Olive oil oleuropein (OLE) and hydroxytyrosol (HT) demonstrated a controversial modulator...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341641/ https://www.ncbi.nlm.nih.gov/pubmed/37446206 http://dx.doi.org/10.3390/ijms241311029 |
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author | Pojero, Fanny Gervasi, Francesco Fiore, Salvatore Davide Aiello, Anna Bonacci, Sonia Caldarella, Rosalia Attanzio, Alessandro Candore, Giuseppina Caruso, Calogero Ligotti, Mattia Emanuela Procopio, Antonio Restivo, Ignazio Tesoriere, Luisa Allegra, Mario Accardi, Giulia |
author_facet | Pojero, Fanny Gervasi, Francesco Fiore, Salvatore Davide Aiello, Anna Bonacci, Sonia Caldarella, Rosalia Attanzio, Alessandro Candore, Giuseppina Caruso, Calogero Ligotti, Mattia Emanuela Procopio, Antonio Restivo, Ignazio Tesoriere, Luisa Allegra, Mario Accardi, Giulia |
author_sort | Pojero, Fanny |
collection | PubMed |
description | Immunosenescence and inflammaging facilitate the insurgence of chronic diseases. The Mediterranean diet is a non-invasive intervention to improve the chronic low-grade inflammatory status associated with aging. Olive oil oleuropein (OLE) and hydroxytyrosol (HT) demonstrated a controversial modulatory action on inflammation in vitro when tested at concentrations exceeding those detectable in human plasma. We studied the potential anti-inflammatory effects of OLE and HT at nutritionally relevant concentrations on peripheral blood mononuclear cells (PBMCs) as regards cell viability, frequency of leukocyte subsets, and cytokine release, performing an age-focused analysis on two groups of subjects: Adult (age 18–64 years) and Senior (age ≥ 65 years). OLE and HT were used alone or as a pre-treatment before challenging PBMCs with lipopolysaccharide (LPS). Both polyphenols had no effect on cell viability irrespective of LPS, but 5 µM HT had an LPS-like effect on monocytes, reducing the intermediate subset in Adult subjects. OLE and HT had no effect on LPS-triggered release of TNF-α, IL-6 and IL-8, but 5 µM HT reduced IL-10 secretion by PBMCs from Adult vs. Senior group. In summary, nutritionally relevant concentrations of OLE and HT elicit no anti-inflammatory effect and influence the frequency of immune cell subsets with age-related different outcomes. |
format | Online Article Text |
id | pubmed-10341641 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103416412023-07-14 Anti-Inflammatory Effects of Nutritionally Relevant Concentrations of Oleuropein and Hydroxytyrosol on Peripheral Blood Mononuclear Cells: An Age-Related Analysis Pojero, Fanny Gervasi, Francesco Fiore, Salvatore Davide Aiello, Anna Bonacci, Sonia Caldarella, Rosalia Attanzio, Alessandro Candore, Giuseppina Caruso, Calogero Ligotti, Mattia Emanuela Procopio, Antonio Restivo, Ignazio Tesoriere, Luisa Allegra, Mario Accardi, Giulia Int J Mol Sci Article Immunosenescence and inflammaging facilitate the insurgence of chronic diseases. The Mediterranean diet is a non-invasive intervention to improve the chronic low-grade inflammatory status associated with aging. Olive oil oleuropein (OLE) and hydroxytyrosol (HT) demonstrated a controversial modulatory action on inflammation in vitro when tested at concentrations exceeding those detectable in human plasma. We studied the potential anti-inflammatory effects of OLE and HT at nutritionally relevant concentrations on peripheral blood mononuclear cells (PBMCs) as regards cell viability, frequency of leukocyte subsets, and cytokine release, performing an age-focused analysis on two groups of subjects: Adult (age 18–64 years) and Senior (age ≥ 65 years). OLE and HT were used alone or as a pre-treatment before challenging PBMCs with lipopolysaccharide (LPS). Both polyphenols had no effect on cell viability irrespective of LPS, but 5 µM HT had an LPS-like effect on monocytes, reducing the intermediate subset in Adult subjects. OLE and HT had no effect on LPS-triggered release of TNF-α, IL-6 and IL-8, but 5 µM HT reduced IL-10 secretion by PBMCs from Adult vs. Senior group. In summary, nutritionally relevant concentrations of OLE and HT elicit no anti-inflammatory effect and influence the frequency of immune cell subsets with age-related different outcomes. MDPI 2023-07-03 /pmc/articles/PMC10341641/ /pubmed/37446206 http://dx.doi.org/10.3390/ijms241311029 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pojero, Fanny Gervasi, Francesco Fiore, Salvatore Davide Aiello, Anna Bonacci, Sonia Caldarella, Rosalia Attanzio, Alessandro Candore, Giuseppina Caruso, Calogero Ligotti, Mattia Emanuela Procopio, Antonio Restivo, Ignazio Tesoriere, Luisa Allegra, Mario Accardi, Giulia Anti-Inflammatory Effects of Nutritionally Relevant Concentrations of Oleuropein and Hydroxytyrosol on Peripheral Blood Mononuclear Cells: An Age-Related Analysis |
title | Anti-Inflammatory Effects of Nutritionally Relevant Concentrations of Oleuropein and Hydroxytyrosol on Peripheral Blood Mononuclear Cells: An Age-Related Analysis |
title_full | Anti-Inflammatory Effects of Nutritionally Relevant Concentrations of Oleuropein and Hydroxytyrosol on Peripheral Blood Mononuclear Cells: An Age-Related Analysis |
title_fullStr | Anti-Inflammatory Effects of Nutritionally Relevant Concentrations of Oleuropein and Hydroxytyrosol on Peripheral Blood Mononuclear Cells: An Age-Related Analysis |
title_full_unstemmed | Anti-Inflammatory Effects of Nutritionally Relevant Concentrations of Oleuropein and Hydroxytyrosol on Peripheral Blood Mononuclear Cells: An Age-Related Analysis |
title_short | Anti-Inflammatory Effects of Nutritionally Relevant Concentrations of Oleuropein and Hydroxytyrosol on Peripheral Blood Mononuclear Cells: An Age-Related Analysis |
title_sort | anti-inflammatory effects of nutritionally relevant concentrations of oleuropein and hydroxytyrosol on peripheral blood mononuclear cells: an age-related analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341641/ https://www.ncbi.nlm.nih.gov/pubmed/37446206 http://dx.doi.org/10.3390/ijms241311029 |
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