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Humanization of the Reaction Specificity of Mouse Alox15b Inversely Modified the Susceptibility of Corresponding Knock-In Mice in Two Different Animal Inflammation Models

Mammalian arachidonic acid lipoxygenases (ALOXs) have been implicated in the pathogenesis of inflammatory diseases, and its pro- and anti-inflammatory effects have been reported for different ALOX-isoforms. Human ALOX15B oxygenates arachidonic acid to its 15-hydroperoxy derivative, whereas the corre...

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Detalles Bibliográficos
Autores principales:	Schäfer, Marjann, Reisch, Florian, Labuz, Dominika, Machelska, Halina, Stehling, Sabine, Püschel, Gerhard P., Rothe, Michael, Heydeck, Dagmar, Kuhn, Hartmut
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341735/ https://www.ncbi.nlm.nih.gov/pubmed/37446212 http://dx.doi.org/10.3390/ijms241311034

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