Stealth Liposomes Encapsulating a Potent ACAT1/SOAT1 Inhibitor F12511: Pharmacokinetic, Biodistribution, and Toxicity Studies in Wild-Type Mice and Efficacy Studies in Triple Transgenic Alzheimer’s Disease Mice

Cholesterol is essential for cellular function and is stored as cholesteryl esters (CEs). CEs biosynthesis is catalyzed by the enzymes acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), with ACAT1 being the primary isoenzyme in most cells in humans. In Alzheimer’s Disease, CEs accumulat...

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Detalles Bibliográficos
Autores principales: De La Torre, Adrianna L., Huynh, Thao N., Chang, Catherine C. Y., Pooler, Darcy B., Ness, Dylan B., Lewis, Lionel D., Pannem, Sanjana, Feng, Yichen, Samkoe, Kimberley S., Hickey, William F., Chang, Ta Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341764/
https://www.ncbi.nlm.nih.gov/pubmed/37446191
http://dx.doi.org/10.3390/ijms241311013

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