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Protein Tyrosine Phosphatase Non-Receptor 11 (PTPN11/Shp2) as a Driver Oncogene and a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC)

PTPN11 encodes the SHP2 protein tyrosine phosphatase that activates the mitogen-activated protein kinase (MAPK) pathway upstream of KRAS and MEK. PTPN11/Shp2 somatic mutations occur frequently in Juvenile myelomonocytic leukaemia (JMML); however, the role of mutated PTPN11 in lung cancer tumourigene...

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Detalles Bibliográficos
Autores principales:	Richards, Cathy E., Elamin, Yasir Y., Carr, Aoife, Gately, Kathy, Rafee, Shereen, Cremona, Mattia, Hanrahan, Emer, Smyth, Robert, Ryan, Daniel, Morgan, Ross K., Kennedy, Susan, Hudson, Lance, Fay, Joanna, O’Byrne, Kenneth, Hennessy, Bryan T., Toomey, Sinead
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341803/ https://www.ncbi.nlm.nih.gov/pubmed/37445722 http://dx.doi.org/10.3390/ijms241310545

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