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The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake?
Human blood has historically been considered a sterile environment. Recently, a thriving microbiome dominated by Firmicutes, Actinobacteria, Proteobacteria, and Bacteroidetes phyla was detected in healthy blood. The localization of these microbes is restricted to some blood cell populations, particu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341833/ https://www.ncbi.nlm.nih.gov/pubmed/37445600 http://dx.doi.org/10.3390/ijms241310422 |
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author | Sciarra, Francesca Franceschini, Edoardo Campolo, Federica Venneri, Mary Anna |
author_facet | Sciarra, Francesca Franceschini, Edoardo Campolo, Federica Venneri, Mary Anna |
author_sort | Sciarra, Francesca |
collection | PubMed |
description | Human blood has historically been considered a sterile environment. Recently, a thriving microbiome dominated by Firmicutes, Actinobacteria, Proteobacteria, and Bacteroidetes phyla was detected in healthy blood. The localization of these microbes is restricted to some blood cell populations, particularly the peripheral blood mononuclear cells and erythrocytes. It was hypothesized that the blood microbiome originates from the skin–oral–gut axis. In addition, many studies have evaluated the potential of blood microbiome dysbiosis as a prognostic marker in cardiovascular diseases, cirrhosis, severe liver fibrosis, severe acute pancreatitis, type 2 diabetes, and chronic kidney diseases. The present review aims to summarize current findings and most recent evidence in the field. |
format | Online Article Text |
id | pubmed-10341833 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103418332023-07-14 The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake? Sciarra, Francesca Franceschini, Edoardo Campolo, Federica Venneri, Mary Anna Int J Mol Sci Review Human blood has historically been considered a sterile environment. Recently, a thriving microbiome dominated by Firmicutes, Actinobacteria, Proteobacteria, and Bacteroidetes phyla was detected in healthy blood. The localization of these microbes is restricted to some blood cell populations, particularly the peripheral blood mononuclear cells and erythrocytes. It was hypothesized that the blood microbiome originates from the skin–oral–gut axis. In addition, many studies have evaluated the potential of blood microbiome dysbiosis as a prognostic marker in cardiovascular diseases, cirrhosis, severe liver fibrosis, severe acute pancreatitis, type 2 diabetes, and chronic kidney diseases. The present review aims to summarize current findings and most recent evidence in the field. MDPI 2023-06-21 /pmc/articles/PMC10341833/ /pubmed/37445600 http://dx.doi.org/10.3390/ijms241310422 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sciarra, Francesca Franceschini, Edoardo Campolo, Federica Venneri, Mary Anna The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake? |
title | The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake? |
title_full | The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake? |
title_fullStr | The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake? |
title_full_unstemmed | The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake? |
title_short | The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake? |
title_sort | diagnostic potential of the human blood microbiome: are we dreaming or awake? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341833/ https://www.ncbi.nlm.nih.gov/pubmed/37445600 http://dx.doi.org/10.3390/ijms241310422 |
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