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The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake?

Human blood has historically been considered a sterile environment. Recently, a thriving microbiome dominated by Firmicutes, Actinobacteria, Proteobacteria, and Bacteroidetes phyla was detected in healthy blood. The localization of these microbes is restricted to some blood cell populations, particu...

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Detalles Bibliográficos
Autores principales: Sciarra, Francesca, Franceschini, Edoardo, Campolo, Federica, Venneri, Mary Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341833/
https://www.ncbi.nlm.nih.gov/pubmed/37445600
http://dx.doi.org/10.3390/ijms241310422
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author Sciarra, Francesca
Franceschini, Edoardo
Campolo, Federica
Venneri, Mary Anna
author_facet Sciarra, Francesca
Franceschini, Edoardo
Campolo, Federica
Venneri, Mary Anna
author_sort Sciarra, Francesca
collection PubMed
description Human blood has historically been considered a sterile environment. Recently, a thriving microbiome dominated by Firmicutes, Actinobacteria, Proteobacteria, and Bacteroidetes phyla was detected in healthy blood. The localization of these microbes is restricted to some blood cell populations, particularly the peripheral blood mononuclear cells and erythrocytes. It was hypothesized that the blood microbiome originates from the skin–oral–gut axis. In addition, many studies have evaluated the potential of blood microbiome dysbiosis as a prognostic marker in cardiovascular diseases, cirrhosis, severe liver fibrosis, severe acute pancreatitis, type 2 diabetes, and chronic kidney diseases. The present review aims to summarize current findings and most recent evidence in the field.
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spelling pubmed-103418332023-07-14 The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake? Sciarra, Francesca Franceschini, Edoardo Campolo, Federica Venneri, Mary Anna Int J Mol Sci Review Human blood has historically been considered a sterile environment. Recently, a thriving microbiome dominated by Firmicutes, Actinobacteria, Proteobacteria, and Bacteroidetes phyla was detected in healthy blood. The localization of these microbes is restricted to some blood cell populations, particularly the peripheral blood mononuclear cells and erythrocytes. It was hypothesized that the blood microbiome originates from the skin–oral–gut axis. In addition, many studies have evaluated the potential of blood microbiome dysbiosis as a prognostic marker in cardiovascular diseases, cirrhosis, severe liver fibrosis, severe acute pancreatitis, type 2 diabetes, and chronic kidney diseases. The present review aims to summarize current findings and most recent evidence in the field. MDPI 2023-06-21 /pmc/articles/PMC10341833/ /pubmed/37445600 http://dx.doi.org/10.3390/ijms241310422 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sciarra, Francesca
Franceschini, Edoardo
Campolo, Federica
Venneri, Mary Anna
The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake?
title The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake?
title_full The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake?
title_fullStr The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake?
title_full_unstemmed The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake?
title_short The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake?
title_sort diagnostic potential of the human blood microbiome: are we dreaming or awake?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341833/
https://www.ncbi.nlm.nih.gov/pubmed/37445600
http://dx.doi.org/10.3390/ijms241310422
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