ATO Increases ROS Production and Apoptosis of Cells by Enhancing Calpain-Mediated Degradation of the Cancer Survival Protein TG2

Transglutaminase 2 (TG2) is a critical cancer cell survival factor that activates several signalling pathways to foster drug resistance, cancer stem cell survival, metastasis, inflammation, epithelial-mesenchymal transition, and angiogenesis. All-trans retinoic acid (ATRA) and chemotherapy have been...

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Detalles Bibliográficos
Autores principales: Jambrovics, Károly, Póliska, Szilárd, Scholtz, Beáta, Uray, Iván P., Balajthy, Zoltán
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341930/
https://www.ncbi.nlm.nih.gov/pubmed/37446117
http://dx.doi.org/10.3390/ijms241310938

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341930/
https://www.ncbi.nlm.nih.gov/pubmed/37446117
http://dx.doi.org/10.3390/ijms241310938

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