Generation of a Well-Characterized Homozygous Chromodomain-Helicase-DNA-Binding Protein 4(G1003D) Mutant hESC Line Using CRISPR/eCas9 (ULIEGEe001-A-1)

The chromatin remodeler Chromodomain-helicase-DNA-binding protein 4 (CHD4) is crucial for the development of multiple organ systems. Functional mutations of CHD4 have recently been described in a developmental disorder, namely Siffrim-Hitz-Weiss syndrome (SIHIWES). Herein, we have generated a homozy...

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Detalles Bibliográficos
Autores principales: Chohra, Ilyas, Giri, Subhajit, Malgrange, Brigitte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342000/
https://www.ncbi.nlm.nih.gov/pubmed/37445725
http://dx.doi.org/10.3390/ijms241310543

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