Polymer-Functionalized Mitochondrial Transplantation to Fibroblasts Counteracts a Pro-Fibrotic Phenotype

Fibroblast-to-myofibroblast transition (FMT) leads to excessive extracellular matrix (ECM) deposition—a well-known hallmark of fibrotic disease. Transforming growth factor-β (TGF-β) is the primary cytokine driving FMT, and this phenotypic conversion is associated with mitochondrial dysfunction, nota...

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Detalles Bibliográficos
Autores principales: Baudo, Gherardo, Wu, Suhong, Massaro, Matteo, Liu, Haoran, Lee, Hyunho, Zhang, Aijun, Hamilton, Dale J., Blanco, Elvin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342003/
https://www.ncbi.nlm.nih.gov/pubmed/37446100
http://dx.doi.org/10.3390/ijms241310913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342003/
https://www.ncbi.nlm.nih.gov/pubmed/37446100
http://dx.doi.org/10.3390/ijms241310913

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